Disrupting the circadian clock: Gene-specific effects on aging, cancer, and other phenotypes

被引：179
作者：
Yu, Elizabeth A.
Weaver, David R. [1 ]
机构：
[1] Univ Massachusetts, Sch Med, Dept Neurobiol, MD PhD Program, Worcester, MA 01605 USA
来源：
AGING-US | 2011年 / 3卷 / 05期
基金：
美国国家卫生研究院;
关键词：
circadian rhythms; clock; Bmal1; period; cryptochrome; cancer; aging; BREAST-CANCER; CELL-CYCLE; TUMOR-GROWTH; DNA-DAMAGE; REPRODUCTIVE-PERFORMANCE; DEREGULATED EXPRESSION; INDIVIDUAL FIBROBLASTS; REVEALS PERSISTENT; EXCISION-REPAIR; DOWN-REGULATION;
D O I：
10.18632/aging.100323
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The circadian clock imparts 24-hour rhythmicity on gene expression and cellular physiology in virtually all cells. Disruption of the genes necessary for the circadian clock to function has diverse effects, including aging-related phenotypes. Some circadian clock genes have been described as tumor suppressors, while other genes have less clear functions in aging and cancer. In this Review, we highlight a recent study [Dubrovsky et al., Aging 2: 936-944, 2010] and discuss the much larger field examining the relationship between circadian clock genes, circadian rhythmicity, aging-related phenotypes, and cancer.
引用
收藏
页码：479 / 493
页数：15
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