Salmonella pathogenicity islands encoding type III secretion systems

被引：273
作者：
Hansen-Wester, I
Hensel, M
机构：
[1] Univ Erlangen Nurnberg, Inst Klin Mikrobiol Immunol & Hyg, D-91054 Erlangen, Germany
[2] Univ Munich, Lehrstuhl Bakteriol, Max Von Pettenkofer Inst, Munich, Germany
来源：
MICROBES AND INFECTION | 2001年 / 3卷 / 07期
关键词：
Salmonella pathogenicity islands; type III secretion systems; invasion; intracellular pathogenesis;
D O I：
10.1016/S1286-4579(01)01411-3
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Salmonella enterica harbours two Salmonella pathogenicity islands (SPIs) each encoding a type III secretion system for virulence proteins. SPI1 is required for invasion, while systemic infections and intracellular accumulation of Salmonella are dependent on SPI2 function. This review will describe and compare the genetic organisation, evolution, regulation and molecular functions of SPI1 and SPI2. (C) 2001 Editions scientifiques et medicales Elsevier SAS.
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收藏
页码：549 / 559
页数：11
相关论文
共 66 条
[1]   Salmonella SirA is a global regulator of genes mediating enteropathogenesis [J].
Ahmer, BMM ;
van Reeuwijk, J ;
Watson, PR ;
Wallis, TS ;
Heffron, F .
MOLECULAR MICROBIOLOGY, 1999, 31 (03) :971-982
[2]   SALMONELLA-TYPHIMURIUM ACTIVATES VIRULENCE GENE-TRANSCRIPTION WITHIN ACIDIFIED MACROPHAGE PHAGOSOMES [J].
ARANDA, CMA ;
SWANSON, JA ;
LOOMIS, WP ;
MILLER, SI .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (21) :10079-10083
[3]   hilA is a novel ompR/toxR family member that activates the expression of Salmonella typhimurium invasion genes [J].
Bajaj, V ;
Hwang, C ;
Lee, CA .
MOLECULAR MICROBIOLOGY, 1995, 18 (04) :715-727
[4]   Co-ordinate regulation of Salmonella typhimurium invasion genes by environmental and regulatory factors is mediated by control of hilA expression [J].
Bajaj, V ;
Lucas, RL ;
Hwang, C ;
Lee, CA .
MOLECULAR MICROBIOLOGY, 1996, 22 (04) :703-714
[5]   Identification of SopE2, a Salmonella secreted protein which is highly homologous to SopE and involved in bacterial invasion of epithelial cells [J].
Bakshi, CS ;
Singh, VP ;
Wood, MW ;
Jones, PW ;
Wallis, TS ;
Galyov, EE .
JOURNAL OF BACTERIOLOGY, 2000, 182 (08) :2341-2344
[6]   pH-dependent secretion of SseB, a product of the SPI-2 type III secretion system of Salmonella typhimurium [J].
Beuzón, CR ;
Banks, G ;
Deiwick, J ;
Hensel, M ;
Holden, DW .
MOLECULAR MICROBIOLOGY, 1999, 33 (04) :806-816
[7]   INHIBITION OF MACROPHAGE PHAGOSOME-LYSOSOME FUSION BY SALMONELLA-TYPHIMURIUM [J].
BUCHMEIER, NA ;
HEFFRON, F .
INFECTION AND IMMUNITY, 1991, 59 (07) :2232-2238
[8]   Macrophage-dependent induction of the Salmonella pathogenicity island 2 type III secretion system and its role in intracellular survival [J].
Cirillo, DM ;
Valdivia, RH ;
Monack, DM ;
Falkow, S .
MOLECULAR MICROBIOLOGY, 1998, 30 (01) :175-188
[9]   Environmental regulation of Salmonella pathogenicity island 2 gene expression [J].
Deiwick, J ;
Nikolaus, T ;
Erdogan, S ;
Hensel, M .
MOLECULAR MICROBIOLOGY, 1999, 31 (06) :1759-1773
[10]   Mutations in Salmonella pathogenicity island 2 (SP12) genes affecting transcription of SPI1 genes and resistance to antimicrobial agents [J].
Deiwick, J ;
Nikolaus, T ;
Shea, JE ;
Gleeson, C ;
Holden, DW ;
Hensel, M .
JOURNAL OF BACTERIOLOGY, 1998, 180 (18) :4775-4780
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