4-Hydroxyphenylpyruvate Dioxygenase Inhibitors: From Chemical Biology to Agrochemicals

被引：133

作者：

Ndikuryayo, Ferdinand ^{[1
]}

Moosavi, Behrooz ^{[1
]}

Yang, Wen-Chao ^{[1
]}

Yang, Guang-Fu ^{[1
,2
]}

机构：

[1] Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol, Wuhan 430079, Hubei, Peoples R China

[2] Collaborat Innovat Ctr Chem Sci & Engn, Tianjin 30071, Peoples R China

来源：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 2017年 / 65卷 / 39期

基金：

中国国家自然科学基金;

关键词：

4-hydroxyphenylpyruvate dioxygenase; chemical biology; inhibitor; agrochemical; herbicide; P-HYDROXYPHENYLPYRUVATE DIOXYGENASE; SYNECHOCYSTIS SP PCC-6803; MOLECULAR-FIELD ANALYSIS; HYDROXYMANDELATE SYNTHASE; (4-HYDROXYPHENYL)PYRUVATE DIOXYGENASE; HOMOGENTISATE PHYTYLTRANSFERASE; STREPTOMYCES-AVERMITILIS; FUNCTIONAL ASSIGNMENT; HERBICIDAL ACTIVITY; CRYSTAL-STRUCTURES;

D O I：

10.1021/acs.jafc.7b03851

中图分类号：

S [农业科学];

学科分类号：

09 ;

摘要：

The development of new herbicides is receiving considerable attention to control weed biotypes resistant to current herbicides. Consequently, new enzymes are always desired as targets for herbicide discovery. 4-Hydroxyphenylpyruvate dioxygenase (HPPD, EC 1.13.11.27) is an enzyme engaged in photosynthetic activity and catalyzes the transformation of 4-hydroxyphenylpyruvic acid (HPPA) into homogentisic acid (HGA). HPPD inhibitors constitute a promising area of discovery and development of innovative herbicides with some advantages, including excellent crop selectivity, low application rates, and broad-spectrum weed control. HPPD inhibitors have been investigated for agrochemical interests, and some of them have already been commercialized as herbicides. In this review, we mainly focus on the chemical biology of HPPD, discovery of new potential inhibitors, and strategies for engineering transgenic crops resistant to current HPPD-inhibiting herbicides. The conclusion raises some relevant gaps for future research directions.

引用

页码：8523 / 8537

页数：15

共 119 条

[1] Physical mapping and functional assignment of the geranylgeranyl-bacteriochlorophyll reductase gene, bchP, of Rhodobacter sphaeroides [J].

Addlesee, HA ;

Hunter, CN .

JOURNAL OF BACTERIOLOGY, 1999, 181 (23) :7248-7255

[2] Cloning, sequencing and functional assignment of the chlorophyll biosynthesis gene, chlP, of Synechocystis sp PCC 6803 [J].

Addlesee, HA ;

Gibson, LCD ;

Jensen, PE ;

Hunter, CN .

FEBS LETTERS, 1996, 389 (02) :126-130

[3] 4-Hydroxyphenylpyruvate Dioxygenase Inhibitors in Combination with Safeners: Solutions for Modern and Sustainable Agriculture [J].

Ahrens, Hartmut ;

Lange, Gudrun ;

Mueller, Thomas ;

Rosinger, Chris ;

Willms, Lothar ;

van Almsick, Andreas .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2013, 52 (36) :9388-9398

[4] Determination of mesotrione residues and metabolites in crops, soil, and water by liquid chromatography with fluorescence detection [J].

Alferness, P ;

Wiebe, L .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2002, 50 (14) :3926-3934

[5]

Almsick van, 2009, OUTLOOKS PEST MANAGE, V20, P27

[6] The process of structure-based drug design [J].

Anderson, AC .

CHEMISTRY & BIOLOGY, 2003, 10 (09) :787-797

[7] Tocopherol synthesis from homogentisate in Capsicum anuum L. (yellow pepper) chromoplast membranes:: evidence for tocopherol cyclase [J].

Arango, Y ;

Heise, KP .

BIOCHEMICAL JOURNAL, 1998, 336 :531-533

[8]

Batisson I., 2010, CURRENT RES TECHNOLO, V1, P287

[9] Herbicidal 4-hydroxyphenylpyruvate dioxygenase inhibitors-A review of the triketone chemistry story from a Syngenta perspective [J].

Beaudegnies, Renaud ;

Edmunds, Andrew J. F. ;

Fraser, Torquil E. M. ;

Hall, Roger G. ;

Hawkes, Timothy R. ;

Mitchell, Glynn ;

Schaetzer, Juergen ;

Wendeborn, Sebastian ;

Wibley, Jane .

BIOORGANIC & MEDICINAL CHEMISTRY, 2009, 17 (12) :4134-4152

[10] Kinetics of abiotic hydrolysis of isoxaflutole: Influence of pH and temperature in aqueous mineral buffered solutions [J].

Beltran, E ;

Fenet, H ;

Cooper, JF ;

Coste, CM .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2000, 48 (09) :4399-4403

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