COVID-19 pandemic, coronaviruses, and diabetes mellitus

被引：528

作者：

Muniyappa, Ranganath ^{[1
]}

Gubbi, Sriram ^{[1
]}

机构：

[1] Natl Inst Diabet & Digest & Kidney Dis, Clin Endocrine Sect, Diabet Endocrinol & Obes Branch, NIH, Bethesda, MD 20892 USA

来源：

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM | 2020年 / 318卷 / 05期

关键词：

diabetes mellitus; coronavirus; COVID-19; FUNCTIONAL RECEPTOR; ACE2; SARS; EPIDEMIOLOGY; PNEUMONIA;

D O I：

10.1152/ajpendo.00124.2020

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The pandemic of coronavirus disease (COVID-19), a disease caused by severe acute respiratory syndrome coronavirus 2 (SARSCoV-2), is causing substantial morbidity and mortality. Older age and presence of diabetes mellitus, hypertension, and obesity significantly increases the risk for hospitalization and death in COVID-19 patients. In this Perspective, informed by the studies on SARS-CoV-2, Middle East respiratory syndrome (MERS-CoV), and the current literature on SARS-CoV-2, we discuss potential mechanisms by which diabetes modulates the host-viral interactions and host-immune responses. We hope to highlight gaps in knowledge that require further studies pertinent to COVID-19 in patients with diabetes.

引用

页码：E736 / E741

页数：6

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