COVID-19 pandemic, coronaviruses, and diabetes mellitus

被引：531

作者：

Muniyappa, Ranganath ^{[1
]}

Gubbi, Sriram ^{[1
]}

机构：

[1] Natl Inst Diabet & Digest & Kidney Dis, Clin Endocrine Sect, Diabet Endocrinol & Obes Branch, NIH, Bethesda, MD 20892 USA

来源：

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM | 2020年 / 318卷 / 05期

关键词：

diabetes mellitus; coronavirus; COVID-19; FUNCTIONAL RECEPTOR; ACE2; SARS; EPIDEMIOLOGY; PNEUMONIA;

D O I：

10.1152/ajpendo.00124.2020

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The pandemic of coronavirus disease (COVID-19), a disease caused by severe acute respiratory syndrome coronavirus 2 (SARSCoV-2), is causing substantial morbidity and mortality. Older age and presence of diabetes mellitus, hypertension, and obesity significantly increases the risk for hospitalization and death in COVID-19 patients. In this Perspective, informed by the studies on SARS-CoV-2, Middle East respiratory syndrome (MERS-CoV), and the current literature on SARS-CoV-2, we discuss potential mechanisms by which diabetes modulates the host-viral interactions and host-immune responses. We hope to highlight gaps in knowledge that require further studies pertinent to COVID-19 in patients with diabetes.

引用

页码：E736 / E741

页数：6

共 56 条

[41] Epidemiology, Genetic Recombination, and Pathogenesis of Coronaviruses [J].

Su, Shuo ;

Wong, Gary ;

Shi, Weifeng ;

Liu, Jun ;

Lai, Alexander C. K. ;

Zhou, Jiyong ;

Liu, Wenjun ;

Bi, Yuhai ;

Gao, George F. .

TRENDS IN MICROBIOLOGY, 2016, 24 (06) :490-502

[42] Tissue specific up regulation of ACE2 in rabbit model of atherosclerosis by atorvastatin: Role of epigenetic histone modifications [J].

Tikoo, Kulbhushan ;

Patel, Gaurang ;

Kumar, Sandeep ;

Karpe, Pinakin Arun ;

Sanghavi, Maitri ;

Malek, Vajir ;

Srinivasan, K. .

BIOCHEMICAL PHARMACOLOGY, 2015, 93 (03) :343-351

[43]

Walls AC, 2020, CELL, V181, P281, DOI [10.1016/j.cell.2020.02.058, 10.1016/j.cell.2020.11.032]

[44] Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China [J].

Wang, Dawei ;

Hu, Bo ;

Hu, Chang ;

Zhu, Fangfang ;

Liu, Xing ;

Zhang, Jing ;

Wang, Binbin ;

Xiang, Hui ;

Cheng, Zhenshun ;

Xiong, Yong ;

Zhao, Yan ;

Li, Yirong ;

Wang, Xinghuan ;

Peng, Zhiyong .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2020, 323 (11) :1061-1069

[45] Acute respiratory distress syndrome leads to reduced ratio of ACE/ACE2 activities and is prevented by angiotensin-(1-7) or an angiotensin II receptor antagonist [J].

Woesten-van Asperen, Roelie M. ;

Lutter, Rene ;

Specht, Patricia A. ;

Moll, Gert N. ;

van Woensel, Job B. ;

van der Loos, Chris M. ;

van Goor, Harry ;

Kamilic, Jelena ;

Florquin, Sandrine ;

Bos, Albert P. .

JOURNAL OF PATHOLOGY, 2011, 225 (04) :618-627

[46] Imbalance Between Pulmonary Angiotensin-Converting Enzyme and Angiotensin-Converting Enzyme 2 Activity in Acute Respiratory Distress Syndrome [J].

Wosten-van Asperen, Roelie M. ;

Bos, Albert P. ;

Bem, Reinout A. ;

Dierdorp, Barbara S. ;

Dekker, Tamara ;

van Goor, Harry ;

Kamilic, Jelena ;

van der Loos, Chris M. ;

van den Berg, Elske ;

Bruijn, Martijn ;

van Woensel, Job B. ;

Lutter, Rene .

PEDIATRIC CRITICAL CARE MEDICINE, 2013, 14 (09) :E438-E441

[47] Risk Factors Associated With Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease 2019 Pneumonia in Wuhan, China [J].

Wu, Chaomin ;

Chen, Xiaoyan ;

Cai, Yanping ;

Xia, Jia'an ;

Zhou, Xing ;

Xu, Sha ;

Huang, Hanping ;

Zhang, Li ;

Zhou, Xia ;

Du, Chunling ;

Zhang, Yuye ;

Song, Juan ;

Wang, Sijiao ;

Chao, Yencheng ;

Yang, Zeyong ;

Xu, Jie ;

Zhou, Xin ;

Chen, Dechang ;

Xiong, Weining ;

Xu, Lei ;

Zhou, Feng ;

Jiang, Jinjun ;

Bai, Chunxue ;

Zheng, Junhua ;

Song, Yuanlin .

JAMA INTERNAL MEDICINE, 2020, 180 (07) :934-943

[48] ACE and ACE2 activity in diabetic mice [J].

Wysocki, Jan ;

Ye, Minghao ;

Soler, Maria Jose ;

Gurley, Susan B. ;

Xiao, Hong D. ;

Bernstein, Kenneth E. ;

Coffman, Thomas M. ;

Chen, Sheldon ;

Batlle, Daniel .

DIABETES, 2006, 55 (07) :2132-2139

[49] Plasma glucose levels and diabetes are independent predictors for mortality and morbidity in patients with SARS [J].

Yang, J. K. ;

Feng, Y. ;

Yuan, M. Y. ;

Yuan, S. Y. ;

Fu, H. J. ;

Wu, B. Y. ;

Sun, G. Z. ;

Yang, G. R. ;

Zhang, X. L. ;

Wang, L. ;

Xu, X. ;

Xu, X. P. ;

Chan, J. C. N. .

DIABETIC MEDICINE, 2006, 23 (06) :623-628

[50] Prevalence of comorbidities and its effects in patients infected with SARS-CoV-2: a systematic review and meta-analysis [J].

Yang, Jing ;

Zheng, Ya ;

Gou, Xi ;

Pu, Ke ;

Chen, Zhaofeng ;

Guo, Qinghong ;

Ji, Rui ;

Wang, Haojia ;

Wang, Yuping ;

Zhou, Yongning .

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 2020, 94 :91-95

← 1 2 3 4 5 6 →