Abnormal taste perception in mice lacking the type 3 inositol 1,4,5-trisphosphate receptor

被引：129

作者：

Hisatsune, Chihiro ^{[1
,2
]}

Yasumatsu, Keiko ^{[3
]}

Takahashi-Iwanaga, Hiromi ^{[4
]}

Ogawa, Naoko ^{[1
]}

Kuroda, Yukiko ^{[1
]}

Yoshida, Ryusuke ^{[3
]}

Ninomiya, Yuzo ^{[3
]}

Mikoshiba, Katsuhiko ^{[1
,2
,5
]}

机构：

[1] RIKEN, Dev Neurobiol Lab, Brain Res Inst, Wako, Saitama 3510198, Japan

[2] Univ Tokyo, Div Mol Neurobiol, Inst Med Sci, Minato Ku, Tokyo 1088639, Japan

[3] Kyushu Univ, Grad Sch Dent Sci, Sect Oral Neurosci, Higashi Ku, Fukuoka 8128582, Japan

[4] Hokkaido Univ, Sch Med, Dept Anat, Sapporo, Hokkaido 0608638, Japan

[5] Japan Sci & Technol Agcy, ICORP, Calcium Oscillat Project, Chiyoda Ku, Tokyo 1020084, Japan

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 2007年 / 282卷 / 51期

关键词：

D O I：

10.1074/jbc.M705641200

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Inositol 1,4,5-trisphosphate receptor (IP3R) is one of the important calcium channels expressed in the endoplasmic reticulum and has been shown to play crucial roles in various physiological phenomena. Type 3 IP3R is expressed in taste cells, but the physiological relevance of this receptor in taste perception in vivo is still unknown. Here, we show that mice lacking IP(3)R3 show abnormal behavioral and electrophysiological responses to sweet, umami, and bitter substances that trigger G-protein-coupled receptor activation. In contrast, responses to salty and acid tastes are largely normal in the mutant mice. We conclude that IP3R3 is a principal mediator of sweet, bitter, and umami taste perception and would be a missing molecule linking phospholipase C beta 2 to TRPM5 activation.

引用

页码：37225 / 37231

页数：7

共 33 条

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