Evaluation of antimicrobial activity of β-lactam antibiotics using Etest against clinical isolates from 60 medical centres in Japan

被引：15

作者：

Ishii, Y ^{[1
]}

Alba, J ^{[1
]}

Kimura, S ^{[1
]}

Shiroto, K ^{[1
]}

Yamaguchi, K ^{[1
]}

机构：

[1] Toho Univ, Sch Med, Dept Microbiol, Ota Ku, Tokyo 1438540, Japan

来源：

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS | 2005年 / 25卷 / 04期

关键词：

cefepime; beta-lactams; Etest; susceptibility; drug resistance;

D O I：

10.1016/j.ijantimicag.2004.12.003

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

An antimicrobial resistance surveillance study was carried out in 60 medical centres across Japan. Resistance to piperacillin was 10.8% in clinical isolates of Escherichia coli, while 1.3% or fewer isolates were resistant to other beta-lactams. Klebsiella spp. were more susceptible to imipenem, cefepime and cefpirome. Isolates of Enterobacter spp., Citrobacter spp., indole-positive Proteus and Serratia spp. were susceptible to imipenem, cefepime and cefpirome, while Acinetobacter spp. were most susceptible to cefoperazone/sulbactam, imipenem, ceftazidime (5.8% resistance) and cefepime (7.6%). Isolates of Pseudomonas aeruginosa were more susceptible to ceftazidime (12.3% resistance), cefoperazone/sulbactam (12.5%) and cefepime (12.6%) than to piperacillin (15.0%), cefpirome (22.6%) and imipenem (30.8%). The percentage of Japanese imipenem resistant P. aeruginosa clinical isolates was around 30%. (C) 2005 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.

引用

页码：296 / 301

页数：6

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