HLA class II alleles and multiple sclerosis in Tunisian patients

被引：13
|
作者：
Messadi, Amira [1 ]
Najiba, Fekih-Mrissa [1 ]
Ouerhani, Slah [5 ]
Zaweli, Jemel [2 ]
Louatti, Ines [2 ]
Layouni, Sami [1 ]
Nciri, Brahim [1 ]
Bouaicha, Ghaya [1 ]
Kouki, Wafa [1 ]
Yedeas, Mondher [3 ]
Raies, Aly [4 ]
Mrissa, Ridha [2 ]
Gritli, Nasreddine [1 ]
机构：
[1] Mil Hosp Tunis, Dept Hematol, Tunis, Tunisia
[2] Mil Hosp Tunis, Dept Neurol, Tunis, Tunisia
[3] Mil Hosp Tunis, Dept Neurosurg, Tunis, Tunisia
[4] Univ Sci Tunis, Lab Microorganisms & Act Bio Mol, Tunis, Tunisia
[5] Pasteur Inst Tunis, Lab Mol & Cellular Hematol, Tunis, Tunisia
来源：
CLINICAL NEUROLOGY AND NEUROSURGERY | 2010年 / 112卷 / 10期
关键词：
Multiple sclerosis; HLA class II polymorphism; PCR-SSP; Case-control study; HLA-DRB1; ASSOCIATION; DIAGNOSIS; AGE;
D O I：
10.1016/j.clineuro.2010.07.004
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Objective The aim of our study was to investigate the association of HLA-DRB1 and -DQB1 alleles with multiple sclerosis (MS) in a Tunisian population and their effect on age at onset and disease severity Methods 58 MS patients and 105 healthy controls were genotyped for HLA class II alleles by PCR-SSP technique Results An association of MS with HLA-DRB1*15 was found (147% vs 3 8%, OR (95% CI) = 4 34 (1 69-11 39) P-c = 2 5 x 10(-3)) after Bonferroni's correction Moreover the DRB1*15-DQB1*06 (138% vs 28%, OR (95% CI) = 5 44 (1 92-17 41) p(c) = 1 1 x 10(-3)) and DRB1*04-DQB1*04 (86% vs 19% OR (95% CI)- 4 86 (1 36-21 62) p(c) = 0 028) haplotypes were found to confer a susceptibility to multiple sclerosis Conclusion To our knowledge this is the first study performed to analyze the association of HLA-DRB1/DQB1 alleles on MS susceptibility in Tunisia The modern Tunisian gene pool shows some degree of heterogeneity and reflects a significant gene flow from Mediterranean regions (C) 2010 Elsevier B V All rights reserved
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收藏
页码：849 / 852
页数：4
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