Use of feline herpesvirus as a vaccine vector offers alternative applications for feline health

被引：12

作者：

Cottingham, Ellen ^{[1
]}

Johnstone, Thurid ^{[2
]}

Hartley, A. Carol ^{[1
]}

Devlin, M. Joanne ^{[1
]}

机构：

[1] Univ Melbourne, Asia Pacific Ctr Anim Hlth, Melbourne Vet Sch, Parkville, Vic 3010, Australia

[2] Univ Melbourne, U Vet Anim Hosp, Fac Vet & Agr Sci, Werribee, Vic 3030, Australia

来源：

VETERINARY MICROBIOLOGY | 2021年 / 261卷

关键词：

Feline herpesvirus; Felis catus; Viral vector; Feline pathogen; Immunocontraception; ADENOASSOCIATED VIRAL VECTOR; TOXOPLASMA-GONDII; INFECTIOUS PERITONITIS; GLYCOPROTEIN-G; PROTECTIVE IMMUNITY; CHLAMYDIA-PSITTACI; GENE-TRANSFER; FERAL CATS; VIRUS; RECOMBINANT;

D O I：

10.1016/j.vetmic.2021.109210

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Herpesviruses are attractive vaccine vector candidates due to their large double stranded DNA genome and latency characteristics. Within the scope of veterinary vaccines, herpesvirus-vectored vaccines have been well studied and commercially available vectored vaccines are used to help prevent diseases in different animal species. Felid alphaherpesvirus 1 (FHV-1) has been characterised as a vector candidate to protect against a range of feline pathogens. In this review we highlight the methods used to construct FHV-1 based vaccines and their outcomes, while also proposing alternative uses for FHV-1 as a viral vector.

引用

页数：9

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