Progress and prospects for fertility preservation in prepubertal boys with cancer

被引：11

作者：

Gies, Inge ^{[1
]}

De Schepper, Jean ^{[1
]}

Tournaye, Herman ^{[2
,3
]}

机构：

[1] UZ Brussel, Dept Pediat, Div Pediat Endocrinol, B-1090 Jette, Belgium

[2] UZ Brussel, Ctr Reprod Med, B-1090 Jette, Belgium

[3] Vrije Univ Brussel, Testis, Res Grp Biol, Dept Embryol & Genet, Brussels, Belgium

来源：

CURRENT OPINION IN ENDOCRINOLOGY DIABETES AND OBESITY | 2015年 / 22卷 / 03期

关键词：

cancer; fertility preservation; prepubertal; SPERMATOGONIAL STEM-CELLS; TESTICULAR TISSUE; MALE GERMLINE; HUMAN TESTES; IN-VITRO; TRANSPLANTATION; SPERM; CRYOPRESERVATION; XENOGRAFTS; LEUKEMIA;

D O I：

10.1097/MED.0000000000000162

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Purpose of reviewIn the past few years, options for fertility preservation in prepubescent boys have enlarged tremendously.Recent findingsAfter a long period of studies on spermatogonial stem cell (SSC) transplantation in mice, recently successful use of rhesus monkey SSCs for autologous and allogeneic transplantation was demonstrated. Furthermore, newer protocols on transplantation of SSCs back into the testes and on how to mimic the niche environment have been described. Very importantly, a new multiparametric sorting strategy to eliminate cancer contamination from human testis cell suspension has been clarified.SummaryWhile awaiting for more data on safety issues, retrieval and cryopreservation of testicular tissue prior to cancer therapy should be offered, within an experimental context, to prepubertal boys with cancer who are at high risk of fertility loss.

引用

页码：203 / 208

页数：6

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