A New Straightforward Synthesis of 2',3'-Didehydro-2',3'-dideoxy-2'-(2"-(trimethylsilyl)ethylthio)thymidine, Key Intermediate for the Synthesis of 2'-Substituted Thionucleosides

被引：1

作者：

Oliveira, Maralise P. ^{[1
,2
,3
]}

Franco, Lucas L. ^{[2
]}

Lima, Maria C. A. ^{[1
]}

Simoes, Claudia M. O. ^{[4
]}

Galdino, Suely L. ^{[1
]}

Pitta, Ivan R. ^{[1
]}

Decout, Jean-Luc ^{[3
]}

Alves, Ricardo J. ^{[2
]}

机构：

[1] Univ Fed Pernambuco, Inst Nacl Ciencia & Tecnol Inovacao Farmaceut, Lab Planejamento & Sintese Farmacos, BR-50670901 Recife, PE, Brazil

[2] Univ Fed Minas Gerais, Fac Farm, Lab Quim Farmaceut Med, BR-31270901 Belo Horizonte, MG, Brazil

[3] Univ Grenoble 1, UMR CNRS 5063, Dept Pharmacochim Mol, F-38048 Grenoble, France

[4] Univ Fed Santa Catarina, Lab Virol Aplicada, Ciencias Farmaceut, BR-88040900 Florianopolis, SC, Brazil

来源：

JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY | 2015年 / 26卷 / 04期

关键词：

nucleosides; thionucleosides; antiviral; anticancer; NUCLEOSIDE ANALOGS; RIBONUCLEOTIDE REDUCTASES; BIOLOGICAL APPLICATIONS; ANTIVIRAL EVALUATION; SULFUR; DISULFIDES; OLIGONUCLEOTIDES; CHEMISTRY; SULFIDES; SUGAR;

D O I：

10.5935/0103-5053.20150025

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We describe herein a straightforward and efficient preparation of 2',3'-dideoxy-2'-(2''-(trimethylsilyl)ethylthio)thymidine, which allows the preparation of diverse potentially antiviral and/or anticancer nucleosides (disulfides, thiols, sulfides, thiocyanates).

引用

页码：816 / 821

页数：6

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