Aldehyde dehydrogenase 1A1 and 1A3 isoforms-mechanism of activation and regulation in cancer

被引：46
|
作者：
Poturnajova, M. [1 ]
Kozovska, Z. [1 ]
Matuskova, M. [1 ]
机构：
[1] Slovak Acad Sci, Biomed Res Ctr, Canc Res Inst, Dept Mol Oncol, Dubravska Cesta 9, Bratislava 84505, Slovakia
来源：
CELLULAR SIGNALLING | 2021年 / 87卷
关键词：
Aldehyde dehydrogenase; Molecular regulation; Stem cells marker; Transcriptional control; Retinoic acid; TRANS-RETINOIC ACID; STEM-CELLS; FUNCTIONAL-ANALYSIS; DNA METHYLATION; ALDH ACTIVITY; EXPRESSION; INHIBITION; GENE; MARKERS; CXCR4;
D O I：
10.1016/j.cellsig.2021.110120
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
In some types of human cancer, aldehyde dehydrogenases represent stemness markers and their expression is associated with advanced disease stages and poor prognosis. Although several biological functions are mediated by their product Retinoid acid, the molecular mechanism is tissue-dependent and only partially understood. In this review, we summarize the current knowledge about the role of ALDH in solid tumours, especially ALDH1A1 and ALDH1A3 isoforms, regarding the molecular mechanism of their transcription and regulation, and their crosstalk with main molecular pathways resulting in the excessive proliferation, chemoresistance, stem cells properties and invasiveness. The recent knowledge of the regulatory effect of lnRNA on ALDH1A1 and ALDH1A3 is discussed too.
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页数：11
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