Activatory properties of lysophosphatidic acid on human THP-1 cells

被引：17
作者：
D'Aquilio, F.
Procaccini, M.
Izzi, V.
Chiurchiu, V.
Giambra, V.
Carotenuto, F.
Di Nardo, P.
Baldini, P. M.
机构：
[1] Univ Roma Tor Vergata, Dept Biol, I-00133 Rome, Italy
[2] Univ Roma Tor Vergata, Dept Internal Med, Lab Cellular & Mol Cardiol, Rome, Italy
来源：
INFLAMMATION | 2007年 / 30卷 / 05期
关键词：
lysophosphatidic acid; proliferation; reactive oxygen intermediates; arachidonic acid metabolites; LPA receptors;
D O I：
10.1007/s10753-007-9034-2
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Excessive leukocyte proliferation and proinflammatory mediators release represent common phenomena in several chronic inflammatory diseases. Multiple evidences identify lysophosphatidic acid (LPA), a small lipid endowed with pleiotropic activities, as an important modulator of both proliferation and activation of different cell types involved in several inflammation-associated pathologies. However, its possible role on monocyte proinflammatory activation is not fully understood yet. Aim of the present study was to investigate LPA effects on THP-1 cells in terms of proliferation, reactive oxygen intermediates (ROI) production and release of arachidonic acid-derived inflammatory mediators. Actually, LPA significantly increased both DNA synthesis and ROI production as well as prostaglandin E-2 release and the upregulation of LPA(3) receptor expression. These findings identified LPA as both a growth factor and a triggering mediator of proinflammatory response in THP-1 cells.
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收藏
页码：167 / 177
页数：11
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