The effects of oral xylitol administration on bone density in rat femur

被引：17

作者：

Sato, Hirokazu ^{[1
]}

Ide, Yoshiaki ^{[2
]}

Nasu, Masanori ^{[3
]}

Numabe, Yukihiro ^{[1
]}

机构：

[1] Nippon Dent Univ Tokyo, Dept Periodontol, Sch Life Dent Tokyo, Chiyoda Ku, Tokyo 1028159, Japan

[2] Nippon Dent Univ Tokyo, Sect Dev & Regenerat Dent, Sch Life Dent Tokyo, Tokyo 1028159, Japan

[3] Nippon Dent Univ Tokyo, Res Ctr Odontol, Sch Life Dent Tokyo, Tokyo 1028159, Japan

来源：

ODONTOLOGY | 2011年 / 99卷 / 01期

关键词：

Xylitol; Oral administration; Bone density; mu CT; Trabecular bone; DIETARY XYLITOL; DENTAL PLAQUE; STREPTOCOCCUS-MUTANS; CHEWING-GUM; RESORPTION; SUGARS; CHILDREN; SORBITOL; RETARDS; ENZYMES;

D O I：

10.1007/s10266-010-0143-2

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

To examine the effects of oral xylitol administration on rat femur bone density, 36 four-week-old male Wistar rats divided into three groups were fed CE-2 diet (control, n = 12) alone or supplemented with 10% (n = 12) or 20% (n = 12) dietary xylitol for 40 days. Biochemical, morphological, and histological analyses were performed. The 10% and 20% xylitol groups showed higher levels of both serum Ca and alkaline phosphatase activity and lower levels of serum tartrate-resistant acid phosphatase than the control group. Although no significant differences in the three-dimensional bone structure or trabecular bone structure of the femur were observed, both xylitol groups showed significantly higher bone density than the control group. Compared to the control group, the 10% and 20% xylitol groups showed an increase in trabeculae. Thus, oral administration of xylitol appears to affect bone metabolism, leading to increased bone density in rat femur.

引用

页码：28 / 33

页数：6

共 41 条

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