Developmental progress of CRISPR/Cas9 and its therapeutic applications for HIV-1 infection

被引：8
作者：
Deng, Qiudi [1 ]
Chen, Zisheng [2 ]
Shi, Lei [3 ]
Lin, Huafeng [1 ,3 ]
机构：
[1] Jinan Univ, Coll Life Sci & Technol, Dept Biotechnol, Guangzhou 510632, Guangdong, Peoples R China
[2] Guangzhou Med Univ, Affiliated Hosp 6, Dept Resp Med, Qingyuan, Peoples R China
[3] Jinan Univ, Dept Food Safety & Nutr Res, Guangzhou, Guangdong, Peoples R China
来源：
REVIEWS IN MEDICAL VIROLOGY | 2018年 / 28卷 / 05期
关键词：
CCR5; CRISPR/Cas9; gene editing; HIV-1; infection; RNA-GUIDED ENDONUCLEASE; ZINC-FINGER-NUCLEASES; HUMAN T-CELLS; LATENT HIV-1; CRYSTAL-STRUCTURE; PROVIRAL DNA; VIRAL ESCAPE; CAS SYSTEMS; GENE; GENOME;
D O I：
10.1002/rmv.1998
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The CRISPR/Cas9 system has been developed as a powerful tool for targeted gene editing. As a result of technical enhancements in recent years, this technology has become the method of choice for efficiently modifying targeted HIV-1 genome efficiently as part of HIV therapy. CRISPR can be modified to target specific sequences that Cas9 then cuts. In this article, we outline the development of the CRISPR/Cas9 system. We also show how this technology can be used for the prevention and treatment of HIV-1 infection. Optimistically, this technology promises to make a significant impact on the fight against HIV-1 in the future.
引用
收藏
页数：7
相关论文
共 55 条
[11]  
Elfaki M.G., 2014, Biology and Medicine, V6, P1, DOI [10.4172/0974-8369.1000e111, DOI 10.4172/0974-8369.1000E111]
[12]   Detection of treatment-resistant infectious HIV after genome-directed antiviral endonuclease therapy [J].
Feelixge, Harshana S. De Silva ;
Stone, Daniel ;
Pietz, Harlan L. ;
Roychoudhury, Pavitra ;
Greninger, Alex L. ;
Schiffer, Joshua T. ;
Aubert, Martine ;
Jerome, Keith R. .
ANTIVIRAL RESEARCH, 2016, 126 :90-98
[13]   Improving CRISPR-Cas nuclease specificity using truncated guide RNAs [J].
Fu, Yanfang ;
Sander, Jeffry D. ;
Reyon, Deepak ;
Cascio, Vincent M. ;
Joung, J. Keith .
NATURE BIOTECHNOLOGY, 2014, 32 (03) :279-284
[14]   Nucleic acid detection with CRISPR-Cas13a/C2c2 [J].
Gootenberg, Jonathan S. ;
Abudayyeh, Omar O. ;
Lee, Jeong Wook ;
Essletzbichler, Patrick ;
Dy, Aaron J. ;
Joung, Julia ;
Verdine, Vanessa ;
Donghia, Nina ;
Daringer, Nichole M. ;
Freije, Catherine A. ;
Myhrvold, Cameron ;
Bhattacharyya, Roby P. ;
Livny, Jonathan ;
Regev, Aviv ;
Koonin, Eugene V. ;
Hung, Deborah T. ;
Sabeti, Pardis C. ;
Collins, James J. ;
Zhang, Feng .
SCIENCE, 2017, 356 (6336) :438-+
[15]   Development and Applications of CRISPR-Cas9 for Genome Engineering [J].
Hsu, Patrick D. ;
Lander, Eric S. ;
Zhang, Feng .
CELL, 2014, 157 (06) :1262-1278
[16]   A Cas9 Ribonucleoprotein Platform for Functional Genetic Studies of HIV-Host Interactions in Primary Human T Cells [J].
Hultquist, Judd F. ;
Schumann, Kathrin ;
Woo, Jonathan M. ;
Manganaro, Lara ;
McGregor, Michael J. ;
Doudna, Jennifer ;
Simon, Viviana ;
Krogan, Nevan J. ;
Marson, Alexander .
CELL REPORTS, 2016, 17 (05) :1438-1452
[17]   NUCLEOTIDE-SEQUENCE OF THE IAP GENE, RESPONSIBLE FOR ALKALINE-PHOSPHATASE ISOZYME CONVERSION IN ESCHERICHIA-COLI, AND IDENTIFICATION OF THE GENE-PRODUCT [J].
ISHINO, Y ;
SHINAGAWA, H ;
MAKINO, K ;
AMEMURA, M ;
NAKATA, A .
JOURNAL OF BACTERIOLOGY, 1987, 169 (12) :5429-5433
[18]   Identification of genes that are associated with DNA repeats in prokaryotes [J].
Jansen, R ;
van Embden, JDA ;
Gaastra, W ;
Schouls, LM .
MOLECULAR MICROBIOLOGY, 2002, 43 (06) :1565-1575
[19]   Specific Reactivation of Latent HIV-1 by dCas9-SunTag-VP64-mediated Guide RNA Targeting the HIV-1 Promoter [J].
Ji, Haiyan ;
Jiang, Zhengtao ;
Lu, Panpan ;
Ma, Li ;
Liz, Chuan ;
Pan, Hanyu ;
Fill, Zheng ;
Qui, Xiying ;
Wang, Pengfei ;
Deng, Junxiao ;
Yang, Xinyi ;
Wang, Jianhua ;
Zhu, Huanzhang .
MOLECULAR THERAPY, 2016, 24 (03) :508-521
[20]   The structural biology of CRISPR-Cas systems [J].
Jiang, Fuguo ;
Doudna, Jennifer A. .
CURRENT OPINION IN STRUCTURAL BIOLOGY, 2015, 30 :100-111
123456