Developmental progress of CRISPR/Cas9 and its therapeutic applications for HIV-1 infection

被引：8
作者：
Deng, Qiudi [1 ]
Chen, Zisheng [2 ]
Shi, Lei [3 ]
Lin, Huafeng [1 ,3 ]
机构：
[1] Jinan Univ, Coll Life Sci & Technol, Dept Biotechnol, Guangzhou 510632, Guangdong, Peoples R China
[2] Guangzhou Med Univ, Affiliated Hosp 6, Dept Resp Med, Qingyuan, Peoples R China
[3] Jinan Univ, Dept Food Safety & Nutr Res, Guangzhou, Guangdong, Peoples R China
来源：
REVIEWS IN MEDICAL VIROLOGY | 2018年 / 28卷 / 05期
关键词：
CCR5; CRISPR/Cas9; gene editing; HIV-1; infection; RNA-GUIDED ENDONUCLEASE; ZINC-FINGER-NUCLEASES; HUMAN T-CELLS; LATENT HIV-1; CRYSTAL-STRUCTURE; PROVIRAL DNA; VIRAL ESCAPE; CAS SYSTEMS; GENE; GENOME;
D O I：
10.1002/rmv.1998
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The CRISPR/Cas9 system has been developed as a powerful tool for targeted gene editing. As a result of technical enhancements in recent years, this technology has become the method of choice for efficiently modifying targeted HIV-1 genome efficiently as part of HIV therapy. CRISPR can be modified to target specific sequences that Cas9 then cuts. In this article, we outline the development of the CRISPR/Cas9 system. We also show how this technology can be used for the prevention and treatment of HIV-1 infection. Optimistically, this technology promises to make a significant impact on the fight against HIV-1 in the future.
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页数：7
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