Asymmetric nickel-catalyzed negishi cross-couplings of secondary α-bromo amides with organozinc reagents

被引：265
|
作者：
Fischer, C [1 ]
Fu, GC [1 ]
机构：
[1] MIT, Dept Chem, Cambridge, MA 02139 USA
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2005年 / 127卷 / 13期
关键词：
D O I：
10.1021/ja0506509
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A Ni/Pybox catalyst achieves the asymmetric cross-coupling of secondary α-bromo amides with organozinc reagents. The process tolerates a variety of functional groups and affords the desired product in good yield and in high enantiomeric excess. Copyright © 2005 American Chemical Society.
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收藏
页码：4594 / 4595
页数：2
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