Acute effects of oestrogen receptor subtype-specific agonists on vascular contractility

被引：31

作者：

Montgomery, S

Shaw, L

Pantelides, N

Taggart, M

Austin, C

机构：

[1] Manchester Royal Infirm, Dept Med, Smooth Muscle Physiol Grp, Manchester M13 9WL, Lancs, England

[2] Univ Manchester, Maternal & Fetal Hlth Res Ctr, Manchester M13 9WL, Lancs, England

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 2003年 / 139卷 / 07期

关键词：

oestrogen receptor agonists; artery; contractility;

D O I：

10.1038/sj.bjp.0705368

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

This study shows for the first time that both the putatively selective oestrogen receptor alpha and oestrogen receptor beta agonists PPT (4,4',4"-(4-propyl-[H-1]-pyrazole-1,3,5-triyl) tris-phenol) and DPN (2,3-bis(4-hydroxyphenyl)-propionitrile) can acutely relax precontracted isolated rat mesenteric arteries at pharmacological (i.e. muM) concentrations. When compared to responses observed to similar concentrations of 17beta-oestrogen obtained on the same tissues, PPT had a significantly greater vasodilatory effect, while DPN had a significantly smaller effect. All responses were rapid being complete within 5 min exposure time. Thus, both PPT and DPN can acutely relax isolated mesenteric arteries with the relative potency of PPT > 17beta-oestrogen > DPN.

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收藏

页码：1249 / 1253

页数：5

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