The novel miR-9501 inhibits cell proliferation, migration and activates apoptosis in non-small cell lung cancer

被引：22

作者：

Xi, Yongyong ^{[1
]}

Wang, Liang ^{[1
]}

Sun, Chengcao ^{[1
]}

Yang, Cuili ^{[1
]}

Zhang, Feng ^{[1
]}

Li, Dejia ^{[1
]}

机构：

[1] Wuhan Univ, Sch Publ Hlth, Dept Occupat & Environm Hlth, 115 Donghu Rd Wuhan, Wuhan 430071, Hubei, Peoples R China

来源：

MEDICAL ONCOLOGY | 2016年 / 33卷 / 11期

基金：

中国国家自然科学基金;

关键词：

Hsa-miRNA-9501 (miR-9501); Non-small cell lung cancer (NSCLC); Proliferation; DOWN-REGULATION; C-MET; MICRORNA; METASTASIS; SUPPRESSES; INVASION; GROWTH; NSCLC; EXPRESSION; PATHWAYS;

D O I：

10.1007/s12032-016-0837-6

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Accumulating evidences suggest that lots of microRNAs (miRNAs) play crucial roles in (patho-)physiological processes of lung cancer, including metastasis, drug-resistance or tumorigenesis. They mediate the progression of cell growth, migration and invasion by regulating the expression of special genes. MiRNA expression patterns could also serve as diagnostic/prognostic biomarkers. Cancer therapies mediated by miRNAs remain tremendous potential and challenges. Our previous small RNA-seq assay found that the novel miR-9501 was down-regulated in lung cancer tissues compared with adjacent non-cancer tissues. In this study, our results verified that miR-9501 was significantly down-regulated in lung cancer tissues and its expression levels were remarkably suppressed in non-small cell lung cancer cell lines. Then, we characterized and investigated the novel miR-9501 in A549 cells. Transient transfection of miR-9501 into cultured A549 cells led to remarkable decrease in cell proliferation, migration and increase apoptosis. These data demonstrated that miR-9501 might be a tumor suppressor for lung cancer therapy.

引用

页数：8

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