Supernatural T cells: Genetic modification of T cells for cancer therapy

被引：125
作者：
Kershaw, MH [1 ]
Teng, MWL [1 ]
Smyth, MJ [1 ]
Darcy, PK [1 ]
机构：
[1] Peter MacCallum Canc Ctr, Melbourne, Vic 3002, Australia
来源：
NATURE REVIEWS IMMUNOLOGY | 2005年 / 5卷 / 12期
基金：
英国医学研究理事会;
关键词：
D O I：
10.1038/nri1729
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Immunotherapy is receiving much attention as a means of treating cancer, but complete, durable responses remain rare for most malignancies. The natural immune system seems to have limitations and deficiencies that might affect its ability to control malignant disease. An alternative to relying on endogenous components in the immune repertoire is to generate lymphocytes with abilities that are greater than those of natural T cells, through genetic modification to produce 'supernatural' T cells. This Review describes how such T cells can circumvent many of the barriers that are inherent in the tumour microenvironment while optimizing T-cell specificity, activation, homing and antitumour function.
引用
收藏
页码：928 / 940
页数：13
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