Altered organization of GABAA receptor mRNA expression in the depressed suicide brain

被引:35
作者
Poulter, Michael O. [1 ,2 ]
Du, Lisheng [3 ,4 ,5 ]
Zhurov, Vladimir [1 ]
Palkovits, Miklos [6 ,7 ]
Faludi, Gabor [8 ]
Merali, Zul [3 ,4 ,5 ]
Anisman, Hymie [2 ]
机构
[1] Univ Western Ontario, Robarts Res Inst, Dept Physiol & Pharmacol, Mol Brain Res Grp, London, ON, Canada
[2] Carleton Univ, Inst Neurosci, Dept Psychol, Ottawa, ON, Canada
[3] Univ Ottawa, Inst Mental Hlth Res, Royal Ottawa Hosp, Ottawa, ON, Canada
[4] Univ Ottawa, Dept Psychol, Ottawa, ON, Canada
[5] Univ Ottawa, Dept Psychiat, Ottawa, ON, Canada
[6] Hungarian Acad Sci, Neuromorphol & Neuroendocrine Res Lab, Budapest, Hungary
[7] Semmelweis Univ, Budapest, Hungary
[8] Semmelweis Univ, Dept Clin & Theoret Mental Hlth, Budapest, Hungary
来源
FRONTIERS IN MOLECULAR NEUROSCIENCE | 2010年 / 3卷
关键词
GABA(A) receptors; human; stress; suicide; depression;
D O I
10.3389/neuro.02.003.2010
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Inter-relationships ordinarily exist between mRNA expression of GABA(A) subunits in the frontopolar cortex (FPC) of individuals that had died suddenly from causes other than suicide. However, these correlations were largely absent in persons that had died by suicide. In the present investigation, these findings were extended by examining GABA(A) receptor expression patterns (of controls and depressed individuals that died by suicide) in the orbital frontal cortex (OFC), hippocampus, amygdala. locus coeruleus (LC) and paraventricular nucleus (PVN), all of which have been implicated in either depression, anxiety or stress responsivity. Using QPCR analysis, we found that in controls the inter-relations between GABA(A) subunits varied across brain regions, being high in the hippocampus and amygdala, intermediate in the LC, and low in the OFC and PVN.The GABA(A) subunit inter-relations were markedly different in persons that died by suicide, being reduced in hippocampus and amygdala, stable in the LC, but more coordinated in the OFC and to some extent in the PVN. It seems that altered brain region-specific inhibitory signaling, stemming from altered GABA(A) subunit coordination, are associated with depression/suicide. Although, it is unknown whether GABA(A) subunit re-organization was specifically tied to depression, suicide, or the accompanying distress, these data show that the coordinated expression of this transcriptome does vary depending on brain region and is plastic.
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页数:10
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