How do lncRNAs regulate transcription?

被引:550
作者
Long, Yicheng [1 ,2 ]
Wang, Xueyin [1 ,2 ]
Youmans, Daniel T. [1 ,2 ,3 ]
Cech, Thomas R. [1 ,2 ]
机构
[1] Univ Colorado, BioFrontiers Inst, Dept Chem & Biochem, Boulder, CO 80309 USA
[2] Univ Colorado, Howard Hughes Med Inst, Boulder, CO 80309 USA
[3] Univ Colorado Denver, Anschutz Med Campus, Aurora, CO 80045 USA
关键词
RNA-POLYMERASE-II; LONG NONCODING RNA; X-CHROMOSOME INACTIVATION; METHYLATED HISTONE H3; 5S RIBOSOMAL-RNA; DOSAGE COMPENSATION; B2; RNA; GENE-EXPRESSION; HEAT-SHOCK; XIST RNA;
D O I
10.1126/sciadv.aao2110
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
It has recently become apparent that RNA, itself the product of transcription, is amajor regulator of the transcriptional process. In particular, long noncoding RNAs (lncRNAs), which are so numerous in eukaryotes, function in many cases as transcriptional regulators. These RNAs function through binding to histone-modifying complexes, to DNA binding proteins (including transcription factors), and even to RNA polymerase II. In other cases, it is the act of lncRNA transcription rather than the lncRNA product that appears to be regulatory. We review recent progress in elucidating themolecular mechanisms by which lncRNAs modulate gene expression and future opportunities in this research field.
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页数:13
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