Anti-epiligrin cicatricial pemphigoid and relative risk for cancer

被引：169

作者：

Egan, CA

Lazarova, Z

Darling, TN

Yee, C

Cotê, T

Yancey, KB

机构：

[1] NCI, Dermatol Branch, Div Clin Sci, NIH, Bethesda, MD 20892 USA

[2] NCI, Canc Stat Branch, NIH, Rockville, MD USA

来源：

LANCET | 2001年 / 357卷 / 9271期

关键词：

D O I：

10.1016/S0140-6736(00)04971-0

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

It is not known whether patients with anti-epiligrin cicatricial pemphigoid (AECP) have an increased risk of malignancy. We calculated the expected numbers of cancers in a cohort of 35 such patients based on respective incidence rates for all cancers In the National Cancer Institute's Surveillance, Epidemiology, and End Results (NCI SEER) Registry. Ten patients in this cohort had solitary solid cancers; eight patients developed cancer after onset of AECP (seven within 14 months). The relative risk (RR) for cancer in this cohort was 6.8 (95% confidence intervals [CI]: 3.3-12.5). AECP seems to be associated with an increased relative risk for cancer.

引用

页码：1850 / 1851

页数：2

共 5 条

[1] EPILIGRIN, THE MAJOR HUMAN KERATINOCYTE INTEGRIN LIGAND, IS A TARGET IN BOTH AN ACQUIRED AUTOIMMUNE AND AN INHERITED SUBEPIDERMAL BLISTERING SKIN-DISEASE [J].