Regional cortical thinning in preclinical Huntington disease and its relationship to cognition

被引：238
|
作者：
Rosas, HD
Hevelone, ND
Zaleta, AK
Greve, DN
Salat, DH
Fischl, B
机构：
[1] Harvard Univ, Sch Med, Ctr Neuroimaging Aging & Neurodegenerat Dis, Charlestown, MA 02129 USA
[2] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Charlestown, MA 02129 USA
[3] Harvard Univ, Sch Med, Dept Neurol, Boston, MA USA
[4] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Boston, MA USA
[5] Athinoula A Martinos Ctr Biomed Imainging, Charlestown, MA USA
来源：
NEUROLOGY | 2005年 / 65卷 / 05期
关键词：
D O I：
10.1212/01.wnl.0000174432.87383.87
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
The authors studied presymptomatic individuals with the Huntington disease (HD) mutation to determine whether cortical thinning was present. They found thinning that was regionally selective, semi-independent of striatal volume loss, and correlated with cognitive performance. Early, extensive cortical involvement occurs during the preclinical stages of HD.
引用
收藏
页码：745 / 747
页数：3
相关论文
共 50 条
  • [1] Regional and progressive thinning of the cortical ribbon in Huntington's disease
    Rosas, HD
    Liu, AK
    Hersch, S
    Glessner, M
    Ferrante, RJ
    Salat, DH
    van der Kouwe, A
    Jenkins, BG
    Dale, AM
    Fischl, B
    NEUROLOGY, 2002, 58 (05) : 695 - 701
  • [2] Cortical thinning in Huntington's disease
    不详
    NEUROSCIENTIST, 2002, 8 (04): : 296 - 296
  • [3] The Relationship of Brain Amyloid Load and APOE Status to Regional Cortical Thinning and Cognition in the ADNI Cohort
    Li, Chunfei
    Loewenstein, David A.
    Duara, Ranjan
    Cabrerizo, Mercedes
    Barker, Warren
    Adjouadi, Malek
    JOURNAL OF ALZHEIMERS DISEASE, 2017, 59 (04) : 1269 - 1282
  • [4] Evaluation of Cognition and Cortical Excitability in Huntington's Disease
    Kamble, Nitish
    Netravathi, M.
    Nagaraju, B. C.
    Lenka, Abhishek
    Kumar, Keshav
    Sowmya, V.
    Jain, Sanjeev
    Pal, Pramod Kumar
    CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES, 2018, 45 (02) : 176 - 181
  • [5] Cortical thinning and its relation to cognition in amyotrophic lateral sclerosis
    Schuster, Christina
    Kasper, Elisabeth
    Dyrba, Martin
    Machts, Judith
    Bittner, Daniel
    Kaufmann, Joern
    Mitchell, Alex J.
    Benecke, Reiner
    Teipel, Stefan
    Vielhaber, Stefan
    Prudlo, Johannes
    NEUROBIOLOGY OF AGING, 2014, 35 (01) : 240 - 246
  • [6] CORTICAL THINNING OF THE OCCIPITAL LOBE IN HUNTINGTON'S DISEASE AND ASSOCIATIONS WITH COGNITIVE PERFORMANCE
    Johnson, E. B.
    Rees, E. M.
    Labuschagne, I.
    Durr, A.
    Leavitt, B. R.
    Roos, R. A. C.
    Johnson, H.
    Hobbs, N. Z.
    Crawford, H. E.
    Langbehn, D. R.
    Stout, J. C.
    Tabrizi, S. J.
    Scahill, R. I.
    JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2014, 85 : A36 - A37
  • [7] Relationship Between CSF Biomarkers of Alzheimer's Disease and Rates of Regional Cortical Thinning in ADNI Data
    Tosun, Duygu
    Schuff, Norbert
    Shaw, Leslie M.
    Trojanowski, John Q.
    Weiner, Michael W.
    JOURNAL OF ALZHEIMERS DISEASE, 2011, 26 : 77 - 90
  • [8] Longitudinal functional magnetic resonance imaging of cognition in preclinical Huntington's disease
    Wolf, Robert Christian
    Sambataro, Fabio
    Vasic, Nenad
    Wolf, Nadine Donata
    Thomann, Philipp Arthur
    Landwehrmeyer, G. Bernhard
    Orth, Michael
    EXPERIMENTAL NEUROLOGY, 2011, 231 (02) : 214 - 222
  • [9] Cortical signatures of cognition and their relationship to Alzheimer's disease
    Gross, Alden L.
    Manly, Jennifer J.
    Pa, Judy
    Johnson, Julene K.
    Park, Lovingly Quitania
    Mitchell, Meghan B.
    Melrose, Rebecca J.
    Inouye, Sharon K.
    McLaren, Donald G.
    BRAIN IMAGING AND BEHAVIOR, 2012, 6 (04) : 584 - 598
  • [10] Cortical signatures of cognition and their relationship to Alzheimer’s disease
    Alden L. Gross
    Jennifer J. Manly
    Judy Pa
    Julene K. Johnson
    Lovingly Quitania Park
    Meghan B. Mitchell
    Rebecca J. Melrose
    Sharon K. Inouye
    Donald G. McLaren
    Brain Imaging and Behavior, 2012, 6 : 584 - 598
12345