Impact of Soluble HLA-G Levels and Endometrial NK Cells in Uterine Flushing Samples from Primary and Secondary Unexplained Infertile Women

被引：20

作者：

Rizzo, Roberta ^{[1
]}

Lo Monte, Giuseppe ^{[2
,3
]}

Bortolotti, Daria ^{[1
]}

Graziano, Angela ^{[2
,3
]}

Gentili, Valentina ^{[1
]}

Di Luca, Dario ^{[1
]}

Marci, Roberto ^{[2
,3
]}

机构：

[1] Univ Ferrara, Sect Microbiol & Genet, Dept Med Sci, I-44100 Ferrara, Italy

[2] Univ Ferrara, Dept Morphol Surg & Expt Med, Sect Gynecol & Obstet, I-44100 Ferrara, Italy

[3] Univ Hosp S Anna, I-44100 Ferrara, Italy

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2015年 / 16卷 / 03期

关键词：

LEUKOCYTE ANTIGEN-G; NATURAL-KILLER-CELLS; PREGNANCY;

D O I：

10.3390/ijms16035510

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The aim of this research was to determine the levels of human leukocyte antigen G (HLA-G) and endometrial Natural Killer ((e)NK) cell percentages in uterine flushing samples from primary and secondary infertile women. sHLA-G levels were lower in the uterine flushing samples from primary infertile women in comparison with women with secondary infertility. Lower CD56(+)KIR2DL4(+) (e)NK cell percentages were detected in primary infertile women compared with secondary infertile women. This is the first study demonstrating that primary and secondary unexplained infertilities are characterized by different basal sHLA-G levels and CD56(+)KIR2DL4(+) (e)NK cell percentages.

引用

页码：5510 / 5516

页数：7

共 12 条

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