A novel SNP in hPer2 associates with diurnal preference in a healthy population

被引：16

作者：

Matsuo, Masahiro ^{[1
]}

Shino, Yayoi ^{[1
]}

Yamada, Naoto ^{[2
]}

Ozeki, Yuji ^{[1
,3
]}

Okawa, Masako ^{[1
]}

机构：

[1] Shiga Univ Med Sci, Dept Psychiat, Shiga 5202192, Japan

[2] Kitatsushima Hosp, Dept Psychiat, Aichi, Japan

[3] Natl Inst Neurosci, Dept Mental Disorder Res, Natl Ctr Neurol & Psychiat, Tokyo, Japan

来源：

SLEEP AND BIOLOGICAL RHYTHMS | 2007年 / 5卷 / 02期

关键词：

circadian rhythm; diurnal preference; hPer2; single nucleotide polymorphism;

D O I：

10.1111/j.1479-8425.2007.00264.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Several studies have shown that polymorphisms of clock genes are associated with diurnal preferences. We investigated whether other polymorphisms also are related to diurnal preference. Our examination targeted the region around the phosphorylation site of hPer2, as a previous report has shown that one single nucleotide polymorphism (SNP) at this site causes familial advanced sleep phase syndrome. We found three other SNPs in this region, with one synonymous SNP significantly correlated to diurnal preference in a healthy population. Although no functional relevance was predicted, this result indicates that diurnal preference in a healthy population is associated with this synonymous SNP of the hPer2 gene.

引用

收藏

页码：141 / 145

页数：5

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