A comparative study between mixed-type tumours from human salivary and canine mammary glands

被引:25
作者
Genelhu, Marisa C. L. S. [1 ,2 ,3 ]
Cardoso, Sergio V. [4 ,5 ]
Gobbi, Helenice [2 ]
Cassali, Geovanni D. [1 ]
机构
[1] Univ Fed Minas Gerais, Inst Biol Sci, Lab Comparat Pathol, Belo Horizonte, MG, Brazil
[2] Univ Fed Minas Gerais, Sch Med, Dept Pathol & Forens Med, Belo Horizonte, MG, Brazil
[3] Vale Rio Doce Univ, Immunol Res Lab, Governador Valadares, MG, Brazil
[4] Univ Fed Uberlandia, Sch Dent, Oral Pathol Lab, Belo Horizonte, MG, Brazil
[5] Univ Estadual Montes Claros, Dept Dent, Belo Horizonte, MG, Brazil
关键词
D O I
10.1186/1471-2407-7-218
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background: In comparative pathology, canine mammary tumours have special interest because of their similarities with human breast cancer. Mixed tumours are uncommon lesions in the human breast, but they are found most frequently in the mammary gland of the female dogs and in the human salivary glands. The aim of the study was to compare clinical, morphological and immunohistochemical features of human salivary and canine mammary gland mixed tumours, in order to evaluate the latter as an experimental model for salivary gland tumours. Methods: Ten examples of each mixed tumour type ( human pleomorphic adenoma and carcinomas ex-pleomorphic adenomas and canine mixed tumour and metaplastic carcinoma) were evaluated. First, clinical and morphologic aspects of benign and malignant variants were compared between the species. Then, streptavidin-biotin-peroxidase immunohistochemistry was performed to detect the expression of cytokeratins, vimentin, p63 protein, estrogen receptor, beta-catenin, and E-cadherin. Results: After standardization, similar age and site distributions were observed in human and canine tumours. Histological similarities were identified in the comparison of the benign lesions as well. Metaplastic carcinomas also resembled general aspects of carcinomas ex-pleomorphic adenomas in morphological evaluation. Additionally, immunohistochemical staining further presented similar antigenic expression between lesions. Conclusion: There are many similar features between human salivary and canine mammary gland mixed tumours. This observation is of great relevance for those interested in the study and management of salivary gland tumours, since canine lesions may constitute useful comparative models for their investigations.
引用
收藏
页数:9
相关论文
共 66 条
  • [31] Genome sequence, comparative analysis and haplotype structure of the domestic dog
    Lindblad-Toh, K
    Wade, CM
    Mikkelsen, TS
    Karlsson, EK
    Jaffe, DB
    Kamal, M
    Clamp, M
    Chang, JL
    Kulbokas, EJ
    Zody, MC
    Mauceli, E
    Xie, XH
    Breen, M
    Wayne, RK
    Ostrander, EA
    Ponting, CP
    Galibert, F
    Smith, DR
    deJong, PJ
    Kirkness, E
    Alvarez, P
    Biagi, T
    Brockman, W
    Butler, J
    Chin, CW
    Cook, A
    Cuff, J
    Daly, MJ
    DeCaprio, D
    Gnerre, S
    Grabherr, M
    Kellis, M
    Kleber, M
    Bardeleben, C
    Goodstadt, L
    Heger, A
    Hitte, C
    Kim, L
    Koepfli, KP
    Parker, HG
    Pollinger, JP
    Searle, SMJ
    Sutter, NB
    Thomas, R
    Webber, C
    Lander, ES
    [J]. NATURE, 2005, 438 (7069) : 803 - 819
  • [32] Study of minor salivary gland mucoepidermoid carcinoma differentiation based on immunohistochemical expression of cytokeratins, vimentin and muscle-specific actin
    Loyola, AM
    de Sousa, SOM
    Araújo, NS
    Araújo, VC
    [J]. ORAL ONCOLOGY, 1998, 34 (02) : 112 - 118
  • [33] Macleod KF, 1999, J PATHOL, V187, P43, DOI 10.1002/(SICI)1096-9896(199901)187:1<43::AID-PATH246>3.0.CO
  • [34] 2-P
  • [35] ESTROGEN-RECEPTOR ASSAY IN POLYMORPHOUS LOW-GRADE ADENOCARCINOMA AND ADENOID CYSTIC CARCINOMA OF SALIVARY-GLAND ORIGIN - AN IMMUNOHISTOCHEMICAL STUDY
    MILLER, AS
    HARTMAN, GG
    CHEN, SY
    EDMONDS, PR
    BRIGHTMAN, SA
    HARWICK, RD
    [J]. ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTOLOGY, 1994, 77 (01): : 36 - 40
  • [36] MISDORP W, 1999, INT HISTOLOGICAL CLA, V2
  • [37] MOTTOLESE M, 1994, LAB INVEST, V71, P182
  • [38] Immunohistologic detection of estrogen receptor alpha in canine mammary tumors:: Clinical and pathologic associations and prognostic significance
    Nieto, A
    Peña, L
    Pérez-Alenza, MD
    Sánchez, MA
    Flores, JM
    Castaño, M
    [J]. VETERINARY PATHOLOGY, 2000, 37 (03) : 239 - 247
  • [39] Nollet F, 1999, Mol Cell Biol Res Commun, V2, P77, DOI 10.1006/mcbr.1999.0155
  • [40] OWEN LN, 1979, INVEST CELL PATHOL, V2, P257