Rats with different profiles of impulsive choice behavior exhibit differences in responses to caffeine and d-amphetamine and in medial prefrontal cortex 5-HT utilization

被引：40

作者：

Barbelivien, Alexandra ^{[1
]}

Billy, Erwan ^{[1
]}

Lazarus, Christine ^{[1
]}

Kelche, Christian ^{[1
]}

Majchrzak, Monique ^{[1
]}

机构：

[1] Univ Strasbourg 1, CNRS, Lab Imagerie & Neurosci Cognit, UMR 7191, F-67000 Strasbourg, France

来源：

BEHAVIOURAL BRAIN RESEARCH | 2008年 / 187卷 / 02期

关键词：

attention-deficit hyperactivity disorder; dopamine; impulsivity; monoamines; psychostimulants;

D O I：

10.1016/j.bbr.2007.09.020

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

This study investigated if sub-populations of rats characterized by their basal level of impulsivity (BLI) in a delayed-reinforcement task, displayed differences in the functioning of neurotransmitter systems modulating impulsive choice behavior. For this, the effects of various doses of caffeine and d-amphetamine were investigated in three sub-populations of rats displaying pronounced differences in their impulsive choice behavior and their post-mortem serotonergic and dopaminergic functions were assessed. Caffeine and d-amphetamine reduce impulsive choice behavior only in the Medium BLI sub-population. Dopamine utilization was similar in the three sub-populations, but serotonin utilization was lower in the prefrontal cortex of the Medium and Very high BLI sub-populations as compared to the low BLI one. These results suggest that anti-impulsive effects of caffeine and d-amphetamine are dependent on the BLI of rats and that a low serotonergic function in the prefrontal cortex may be a trait marker of impulsivity evaluated by impulsive choice behavior. (C) 2007 Elsevier B.V. All rights reserved.

引用

页码：273 / 283

页数：11

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