Rats with different profiles of impulsive choice behavior exhibit differences in responses to caffeine and d-amphetamine and in medial prefrontal cortex 5-HT utilization

被引：40
作者：
Barbelivien, Alexandra [1 ]
Billy, Erwan [1 ]
Lazarus, Christine [1 ]
Kelche, Christian [1 ]
Majchrzak, Monique [1 ]
机构：
[1] Univ Strasbourg 1, CNRS, Lab Imagerie & Neurosci Cognit, UMR 7191, F-67000 Strasbourg, France
来源：
BEHAVIOURAL BRAIN RESEARCH | 2008年 / 187卷 / 02期
关键词：
attention-deficit hyperactivity disorder; dopamine; impulsivity; monoamines; psychostimulants;
D O I：
10.1016/j.bbr.2007.09.020
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
This study investigated if sub-populations of rats characterized by their basal level of impulsivity (BLI) in a delayed-reinforcement task, displayed differences in the functioning of neurotransmitter systems modulating impulsive choice behavior. For this, the effects of various doses of caffeine and d-amphetamine were investigated in three sub-populations of rats displaying pronounced differences in their impulsive choice behavior and their post-mortem serotonergic and dopaminergic functions were assessed. Caffeine and d-amphetamine reduce impulsive choice behavior only in the Medium BLI sub-population. Dopamine utilization was similar in the three sub-populations, but serotonin utilization was lower in the prefrontal cortex of the Medium and Very high BLI sub-populations as compared to the low BLI one. These results suggest that anti-impulsive effects of caffeine and d-amphetamine are dependent on the BLI of rats and that a low serotonergic function in the prefrontal cortex may be a trait marker of impulsivity evaluated by impulsive choice behavior. (C) 2007 Elsevier B.V. All rights reserved.
引用
收藏
页码：273 / 283
页数：11
相关论文
共 40 条
  • [1] Differential effects of caffeine on dopamine and acetylcholine transmission in brain areas of drug-naive and caffeine-pretreated rats
    Acquas, E
    Tanda, G
    Di Chiara, G
    [J]. NEUROPSYCHOPHARMACOLOGY, 2002, 27 (02) : 182 - 193
  • [2] Acetyl-L-carnitine reduces impulsive behaviour in adolescent rats
    Adriani, W
    Rea, M
    Baviera, M
    Invernizzi, W
    Carli, M
    Ghirardi, O
    Caprioli, A
    Laviola, G
    [J]. PSYCHOPHARMACOLOGY, 2004, 176 (3-4) : 296 - 304
  • [3] The spontaneously hypertensive-rat as an animal model of ADHD: evidence for impulsive and non-impulsive subpopulations
    Adriani, W
    Caprioli, A
    Granstrem, O
    Carli, M
    Laviola, G
    [J]. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 2003, 27 (07) : 639 - 651
  • [4] [Anonymous], RAT BRAIN STEREOTAXI
  • [5] IMPROVED METHOD FOR DETERMINATION OF ACETYLCHOLINE, CHOLINE, AND OTHER BIOGENIC-AMINES IN A SINGLE BRAIN-TISSUE SAMPLE USING HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY AND ELECTROCHEMICAL DETECTION
    BELEY, A
    ZEKHNINI, A
    LARTILLOT, S
    FAGE, D
    BRALET, J
    [J]. JOURNAL OF LIQUID CHROMATOGRAPHY, 1987, 10 (13): : 2977 - 2992
  • [6] Serotonin and tolerance to delay of reward in rats
    Bizot, JC
    Le Bihan, C
    Puech, AJ
    Hamon, M
    Thiébot, MH
    [J]. PSYCHOPHARMACOLOGY, 1999, 146 (04) : 400 - 412
  • [7] The effects of d-amphetamine, chlordiazepoxide, α-flupenthixol and behavioural manipulations on choice of signalled and unsignalled delayed reinforcement in rats
    Cardinal, RN
    Robbins, TW
    Everitt, BJ
    [J]. PSYCHOPHARMACOLOGY, 2000, 152 (04) : 362 - 375
  • [8] Neuroscience of attention-deficit/hyperactivity disorder: The search for endophenotypes
    Castellanos, FX
    Tannock, R
    [J]. NATURE REVIEWS NEUROSCIENCE, 2002, 3 (08) : 617 - 628
  • [9] Deficits in impulse control associated with tonically-elevated function in rat serotonergic prefrontal cortex
    Dalley, JW
    Theobald, DE
    Eagle, DM
    Passetti, F
    Robbins, TW
    [J]. NEUROPSYCHOPHARMACOLOGY, 2002, 26 (06) : 716 - 728
  • [10] Caffeine and accumbens shell dopamine
    De Luca, M. A.
    Bassareo, V.
    Bauer, A.
    Di Chiara, G.
    [J]. JOURNAL OF NEUROCHEMISTRY, 2007, 103 (01) : 157 - 163
1234