Segmentation of small animal PET/CT mouse brain scans using an MRI-based 3D digital atlas

被引：2
作者：
Delzescaux, Thierry
Lebenberg, Jessica
Raguet, Hugo
Hantraye, Philippe
机构：
来源：
2010 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC) | 2010年
关键词：
IMAGES;
D O I：
10.1109/IEMBS.2010.5626106
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
The work reported in this paper aimed at developing and testing an automated method to calculate the biodistribution of a specific PET tracer in mouse brain PET/CT images using an MRI-based 3D digital atlas. Surface-based registration strategy and affine transformation estimation were considered. Such an approach allowed overcoming the lack of anatomical information in the inner regions of PET/CT brain scans. Promising results were obtained in one mouse (on two scans) and will be extended to a neuroinflammation mouse model to characterize the pathology and its evolution. Major improvements are expected regarding automation, time computation, robustness and reproducibility of mouse brain segmentation. Due to its generic implementation, this method could be successfully applied to PET/CT brain scans of other species (rat, primate) for which 3D digital atlases are available.
引用
收藏
页码：3097 / 3100
页数：4
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