Mediterranean Diet, Alzheimer Disease Biomarkers, and Brain Atrophy in Old Age

被引：91

作者：

Ballarini, Tommaso ^{[1
]}

van Lent, Debora Melo ^{[1
,2
]}

Brunner, Julia ^{[1
]}

Schroeder, Alina ^{[1
]}

Wolfsgruber, Steffen ^{[1
,3
]}

Altenstein, Slawek ^{[4
]}

Brosseron, Frederic ^{[1
,3
]}

Buerger, Katharina ^{[5
]}

Dechent, Peter ^{[7
]}

Dobisch, Laura ^{[6
,8
]}

Duezel, Emrah ^{[6
,8
]}

Ertl-Wagner, Birgit ^{[9
]}

Fliessbach, Klaus ^{[1
,3
]}

Freiesleben, Silka Dawn ^{[10
]}

Frommann, Ingo ^{[1
]}

Glanz, Wenzel ^{[6
]}

Hauser, Dietmar ^{[10
]}

Haynes, John Dylan ^{[11
]}

Heneka, Michael T. ^{[1
,3
]}

Janowitz, Daniel ^{[6
]}

Kilimann, Ingo ^{[12
,13
]}

Laske, Christoph ^{[5
,14
,15
]}

Maier, Franziska ^{[16
]}

Metzger, Coraline Danielle ^{[6
,8
]}

Munk, Matthias ^{[5
,14
,15
]}

Perneczky, Robert ^{[5
,17
,18
,19
]}

Peters, Oliver ^{[10
]}

Priller, Josef ^{[4
]}

Ramirez, Alfredo ^{[16
]}

Rauchmann, Boris ^{[17
]}

Roy, Nina ^{[1
]}

Scheffler, Klaus ^{[20
]}

Schneider, Anja ^{[1
,3
]}

Spottke, Annika ^{[1
,21
]}

Spruth, Eike Jakob ^{[4
]}

Teipel, Stefan J. ^{[12
,13
]}

Vukovich, Ruth ^{[22
]}

Wiltfang, Jens ^{[22
,23
,24
,25
]}

Jessen, Frank ^{[1
,16
,26
]}

Wagner, Michael ^{[1
,3
]}

机构：

[1] German Ctr Neurodegenerat Dis DZNE, Venusberg Campus 1, Bonn, Germany

[2] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA

[3] Univ Hosp Bonn, Dept Neurodegenerat & Geriatr Psychiat, Venusberg Campus 1, Bonn, Germany

[4] Charite, Dept Psychiat & Psychotherapy, Charitepl 1, Berlin, Germany

[5] German Ctr Neurodegenerat Dis DZNE, Munich, Germany

[6] Ludwig Maximilians Univ Munchen, Univ Hosp, Inst Stroke & Dementia Res ISD, Munich, Germany

[7] Georg August Univ Gottingen, MR Res Neurol & Psychiat, Gottingen, Germany

[8] Otto von Guericke Univ, Inst Cognit Neurol & Dementia Res IKND, Magdeburg, Germany

[9] Ludwig Maximilians Univ Munchen, Inst Clin Radiol, Munich, Germany

[10] Charite Univ Med Berlin, Dept Psychiat & Psychotherapy, Campus Benjamin Franklin, Berlin, Germany

[11] Charite, Bernstein Ctr Computat Neurosci, Berlin, Germany

[12] Rostock Univ, Med Ctr, German Ctr Neurodegenerat Dis DZNE, Rostock, Germany

[13] Rostock Univ, Med Ctr, Dept Psychosomat Med, Rostock, Germany

[14] Univ Tubingen, Sect Dementia Res, Hertie Inst Clin Brain Res, Tubingen, Germany

[15] Univ Tubingen, Dept Psychiat & Psychotherapy, Tubingen, Germany

[16] Univ Cologne, Med Fac, Dept Psychiat, Cologne, Germany

[17] Ludwig Maximilians Univ Munchen, Univ Hosp, Dept Psychiat & Psychotherapy, Munich, Germany

[18] Munich Cluster Syst Neurol SyNergy, Munich, Germany

[19] Imperial Coll London, Sch Publ Hlth, Ageing Epidemiol Res Unit AGE, London, England

[20] Univ Tubingen, Dept Biomed Magnet Resonance, Tubingen, Germany

[21] Univ Bonn, Dept Neurol, Venusberg Campus 1, Bonn, Germany

[22] Univ Goettingen, Univ Med Ctr Goettingen, Dept Psychiat & Psychotherapy, Gottingen, Germany

[23] German Ctr Neurodegenerat Dis DZNE, Gottingen, Germany

[24] Univ Aveiro, Neurosci & Signaling Grp, Inst Biomed iBiMED, Aveiro, Portugal

[25] Univ Aveiro, Dept Med Sci, Aveiro, Portugal

[26] Univ Cologne, Excellence Cluster Cellular Stress Responses Agin, Cologne, Germany

来源：

NEUROLOGY | 2021年 / 96卷 / 24期

关键词：

SUBJECTIVE COGNITIVE DECLINE; PHYSICAL-ACTIVITY; AMYLOID-BETA; IMPAIRMENT; DEMENTIA; RISK; TAU; ASSOCIATION; ADHERENCE; ADULTS;

D O I：

10.1212/WNL.0000000000012067

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Objective To determine whether following a Mediterranean-like diet (MeDi) relates to cognitive functions and in vivo biomarkers for Alzheimer disease (AD), we analyzed cross-sectional data from the German DZNE-Longitudinal Cognitive Impairment and Dementia Study. Method The sample (n = 512, mean age 69.5 +/- 5.9 years) included 169 cognitively normal participants and individuals at higher AD risk (53 with relatives with AD, 209 with subjective cognitive decline, and 81 with mild cognitive impairment). We defined MeDi adherence according to the food frequency questionnaire. Brain volume outcomes were generated via voxel-based morphometry on T1-MRI, and cognitive performance was assessed with an extensive neuropsychological battery. AD-related biomarkers (beta-amyloid(42/40) [A beta(42/40)] ratio, phosphorylated tau 181 [pTau181]) in CSF were assessed in n = 226 individuals. We analyzed the associations between MeDi and outcomes with linear regression models controlling for several covariates. In addition, we applied hypothesis-driven mediation and moderation analysis. Results Higher MeDi adherence related to larger mediotemporal gray matter volume (p < 0.05 family-wise error corrected), better memory (beta +/- SE = 0.03 +/- 0.02; p = 0.038), and less amyloid (A beta(42/40) ratio, beta +/- SE = 0.003 +/- 0.001; p = 0.008) and pTau181 (beta +/- SE = -1.96 +/- 0.68; p = 0.004) pathology. Mediotemporal volume mediated the association between MeDi and memory (40% indirect mediation). Finally, MeDi favorably moderated the associations among A beta(42/40) ratio, pTau181, and mediotemporal atrophy. Results were consistent correcting for APOE-epsilon 4 status. Conclusion Our findings corroborate the view of MeDi as a protective factor against memory decline and mediotemporal atrophy. They suggest that these associations might be explained by a decrease of amyloidosis and tau pathology. Longitudinal and dietary intervention studies should further examine this conjecture and its treatment implications.

引用

页码：E2920 / E2932

页数：13

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