Tenascin-C and integrins in cancer

被引：145

作者：

Yoshida, Toshimichi ^{[1
,2
]}

Akatsuka, Tatsuya ^{[1
]}

Imanaka-Yoshida, Kyoko ^{[1
,2
]}

机构：

[1] Mie Univ, Grad Sch Med, Dept Pathol & Matrix Biol, Tsu, Mie 514, Japan

[2] Mie Univ, Res Ctr Matrix Biol, Tsu, Mie 514, Japan

来源：

CELL ADHESION & MIGRATION | 2015年 / 9卷 / 1-2期

关键词：

cancer cell; integrins; splice variant; Stromal cell; tenascin-C; EPITHELIAL-MESENCHYMAL TRANSITION; MESSENGER-RNA EXPRESSION; SQUAMOUS-CELL CARCINOMA; HUMAN BREAST-CANCER; GROWTH-FACTOR-BETA; SPLICE VARIANTS; ANNEXIN-II; PROTEIN DISTRIBUTION; ENDOTHELIAL-CELLS; COLORECTAL-CANCER;

D O I：

10.1080/19336918.2015.1008332

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Tenascin-C (TNC) is highly expressed in cancer tissues. Its cellular sources are cancer and stromal cells, including fibroblasts/myofibroblasts, and also vascular cells. TNC expressed in cancer tissues dominantly contains large splice variants. Deposition of the stroma promotes the epithelial-mesenchymal transition, proliferation, and migration of cancer cells. It also facilitates the formation of cancer stroma including desmoplasia and angiogenesis. Integrin receptors that mediate the signals of TNC have also been discussed.

引用

页码：96 / 104

页数：9

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