Of Rats and Men: a Translational Model To Understand Vancomycin Pharmacokinetic/Toxicodynamic Relationships

被引：13

作者：

Scheetz, Marc H. ^{[1
,2
,3
]}

Pais, Gwendolyn M. ^{[1
,2
]}

Lodise, Thomas P. ^{[4
]}

Tong, Steven Y. C. ^{[5
,6
,7
]}

Davis, Joshua S. ^{[7
]}

O'Donnell, J. Nicholas ^{[4
]}

Liu, Jiajun ^{[8
]}

Neely, Michael ^{[9
]}

Prozialeck, Walter C. ^{[3
]}

Lamar, Peter C. ^{[3
]}

Rhodes, Nathaniel J. ^{[1
,2
]}

Holland, Thomas ^{[10
,11
]}

Avedissian, Sean N. ^{[12
,13
]}

机构：

[1] Midwestern Univ, Dept Pharm Practice, Chicago Coll Pharm, Downers Grove, IL 60515 USA

[2] Midwestern Univ, Ctr Pharmacometr Excellence, Chicago Coll Pharm, Downers Grove, IL 60515 USA

[3] Midwestern Univ, Dept Pharmacol, Coll Grad Studies, Downers Grove, IL 60515 USA

[4] Albany Coll Pharm & Hlth Sci, Dept Pharm Practice, New York, NY USA

[5] Royal Melbourne Hosp, Peter Doherty Inst Infect & Immun, Victorian Infect Dis Serv, Melbourne, Vic, Australia

[6] Univ Melbourne, Peter Doherty Inst Infect & Immun, Dept Infect Dis, Melbourne, Vic, Australia

[7] Charles Darwin Univ, Menzies Sch Hlth Res, Darwin, NT, Australia

[8] US FDA, Div Pharmacometr, Off Clin Pharmacol, Ctr Drug Evaluat & Res, Silver Spring, MD USA

[9] Univ Southern Calif, Childrens Hosp Los Angeles, Los Angeles, CA 90007 USA

[10] Duke Univ, Sch Med, Durham, NC USA

[11] Duke Clin Res Inst, Durham, NC USA

[12] Univ Nebraska Med Ctr, Ctr Drug Discovery, Antiviral Pharmacol Lab, Omaha, NE USA

[13] Univ Nebraska Med Ctr, Coll Pharm, Omaha, NE USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2021年 / 65卷 / 10期

基金：

美国国家卫生研究院; 英国医学研究理事会;

关键词：

AKI; allometric; glycopeptides; laboratory animals; preclinical; toxicity; vancomycin; PROVIDE; CAMERA2; biomarkers; ACUTE-CARE HOSPITALS; ACUTE KIDNEY INJURY; URINARY BIOMARKERS; TRENDS;

D O I：

10.1128/AAC.01060-21

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Vancomycin area under the concentration curve (AUC) is known to predict vancomycin-induced acute kidney injury (AKI). Data were analyzed from a rat model (n = 48) and two prospective clinical studies (PROVIDE [n = 263] and CAMERA2 [n = 291]). A logit-link model was used to calculate the multiplicative factors between the probability of AKI from clinical studies and in the rat. The rat was 2.7 to 4.2 times more sensitive to AKI between AUCs of 199.5 and 794.3 mg.h/liter, respectively.

引用

页数：5

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