Cytotoxicity and antibacterial studies of iridoids and phenolic compounds isolated from the latex of Himatanthus sucuuba

被引：0

作者：

Silva, Jefferson Rocha A. ^{[1
]}

Rezende, Claudia M. ^{[2
]}

Pinto, Angelo C. ^{[2
]}

Amaral, Ana Claudia F. ^{[3
]}

机构：

[1] Univ Fed Amazonas, Dept Quim, BR-69077000 Manaus, Amazonas, Brazil

[2] Univ Fed Rio de Janeiro, Inst Quim, BR-21945970 Rio de Janeiro, Brazil

[3] Farmanguinhos FIOCRUZ R Sizenando Nabuco, Lab Plantas Med & Derivados, BR-21041250 Manguinho, RJ, Brazil

来源：

AFRICAN JOURNAL OF BIOTECHNOLOGY | 2010年 / 9卷 / 43期

关键词：

Himatanthus sucuuba; iridoids; phenolics; cytotoxicity; antibacterial; MEDICINAL-PLANTS; APOCYNACEAE; WOODSON;

D O I：

暂无

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The latex of Himatanthus sucuuba (Spruce) Woodson, used popularly in the Amazon for the treatment of tumors, gastritis, inflammations and infections, was evaluated for cytotoxicity and antibacterial activities. The iridoid lactones, plumericin and isoplumericin were isolated from latex by bioassay fractionation and were found to be associated with DNA damage. Gallic acid exhibited the highest antimicrobial activity among the phenolic compounds isolated from the aqueous fraction. The compounds associated to cytotoxicity and antimicrobial activities could be responsible to the effects of this species used in traditional medicine.

引用

页码：7357 / 7360

页数：4

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