In Situ Analysis for Herbal Pieces of Aconitum Plants by Using Direct Analysis in Real Time Mass Spectrometry

被引:17
作者
Zhou, Feng [1 ,2 ,3 ]
Zhu, Hongbin [1 ,2 ]
Liu, Shu [1 ,2 ]
Ma, Kang [4 ]
Song, Fengrui [1 ,2 ]
Liu, Zhiqiang [1 ,2 ]
机构
[1] Chinese Acad Sci, Changchun Inst Appl Chem, Natl Ctr Mass Spectrometry Changchun, Changchun 130022, Jilin, Peoples R China
[2] Chinese Acad Sci, Changchun Inst Appl Chem, Jilin Prov Key Lab Chinese Med Chem & Mass Spectr, Changchun 130022, Jilin, Peoples R China
[3] Univ Chinese Acad Sci, Beijing 100039, Peoples R China
[4] Natl Inst Metrol, Food Safety Lab, Beijing 100029, Peoples R China
基金
中国国家自然科学基金;
关键词
real time mass spectrometry (DART-MS); Aconitum plant; in situ analysis; quality; PERFORMANCE LIQUID-CHROMATOGRAPHY; SOLID-PHASE MICROEXTRACTION; WU-TOU DECOCTION; RADIX-ACONITI; INTESTINAL BACTERIA; RAPID IDENTIFICATION; AMBIENT CONDITIONS; ALKALOIDS; METABOLITES; RAT;
D O I
10.1002/cjoc.201400692
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
In this study, an extend application was developed to in situ analyze the herbal pieces of Aconitum plants by Direct Analysis in Real Time Mass Spectrometry (DART-MS). Nearly all aconitine-type alkaloids can be desorbed and ionized in this method, including diester diterpenoid aconitines (DDAs), monoester diterpenoid aconitines (MDAs) and some other diterpenoid aconitines. The spectra of in situ analysis for the herbal pieces of aconitum plants are similar with that of their extracts. Radix Aconiti and Radix Aconiti Kusnezoffii can be distinguished from each other by the intensity differences of character fragment ions from MDAs, such as m/z 586, 572, and 556. The qualified and unqualified herbal pieces can be also identified by the relative abundances of DDAs. The RSD of the relative abundances of some character ions at m/z 556, 586, and 590 were 13.53%, 4.03%, and 12.03%, respectively. So this in situ analytical method can identify both the types of Aconitum preparata and their quality. It provides the following advantages in the analysis of Chinese herbs: fast detection without much pretreatment, high-throughput analysis, and reduction of pollution without any organic solvent.
引用
收藏
页码:241 / 246
页数:6
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