Photosensitizer anchored gold nanorods for targeted combinational photothermal and photodynamic therapy

被引：65

作者：

Tham, Huijun Phoebe ^{[1
,2
,3
]}

Chen, Hongzhong ^{[2
]}

Tan, Yu Hui ^{[2
]}

Qu, Qiuyu ^{[2
]}

Sreejith, Sivaramapanicker ^{[2
]}

Zhao, Lingzhi ^{[2
]}

Venkatraman, Subbu S. ^{[3
]}

Zhao, Yanli ^{[2
,3
]}

机构：

[1] Nanyang Technol Univ, Interdisciplinary Grad Sch, 50 Nanyang Ave, Singapore 639798, Singapore

[2] Nanyang Technol Univ, Sch Phys & Math Sci, Div Chem & Biol Chem, 21 Nanyang Link, Singapore 637371, Singapore

[3] Nanyang Technol Univ, Sch Mat Sci & Engn, 50 Nanyang Ave, Singapore 639798, Singapore

来源：

CHEMICAL COMMUNICATIONS | 2016年 / 52卷 / 57期

关键词：

SKIN-CANCER; NANOPARTICLES; GROWTH;

D O I：

10.1039/c6cc03076a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Silylated zinc phthalocyanine (ZnPc) was anchored onto silica-coated gold nanorods (AuNR) with retained local surface plasmon resonance (LSPR). Independent LSPR and singlet oxygen production of anchored ZnPc enhance the photothermal and photodynamic efficacy of the obtained AuNR-Si-ZnPc under NIR light excitation. AuNR-Si-ZnPc was further grafted with hyaluronic acid (HA). Since HA has selective targeting capability to CD44 antigens, the final hybrid could target cancer cells directly for synergistic photothermal and photodynamic therapy.

引用

页码：8854 / 8857

页数：4

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