CpG motifs: the active ingredient in bacterial extracts?

被引：228
作者：
Krieg, AM [1 ]
机构：
[1] Coley Pharmaceut Grp, Wellesley, MA 02481 USA
来源：
NATURE MEDICINE | 2003年 / 9卷 / 07期
关键词：
D O I：
10.1038/nm0703-831
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The use of bacteria and bacterial extracts for immunotherapy has a checkered past. Recent developments in immunology reveal that these nonspecific immune activators actually work by triggering specific receptors that are expressed by subsets of immune cells. Identification of these receptors and the molecular signaling pathways that they activate has enabled a new era of specific targeted immunotherapy using chemically synthesized mimics of pathogen molecules.
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收藏
页码：831 / 835
页数：5
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