Overnight refrigerator storage of autologous peripheral progenitor stem cells without cryopreservation

被引：7

作者：

Donmez, Ayhan ^{[1
]}

Cagirgan, Seckin ^{[1
]}

Saydam, Guray ^{[1
]}

Tombuloglu, Murat ^{[1
]}

机构：

[1] Ege Univ, Sch Med, Dept Hematol, TR-35100 Izmir, Turkey

来源：

TRANSFUSION AND APHERESIS SCIENCE | 2007年 / 36卷 / 03期

关键词：

peripheral blood progenitor cells; overnight storage; engraftment;

D O I：

10.1016/j.transci.2007.03.011

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We compared cryopreservation of peripheral blood progenitor cell (PBPC) products immediately and after overnight storage. There was no statistically significant difference in the groups regarding median CD34+ cell count of the product, storage duration at -80 degrees C, viability rates, neutrophil and platelet engraftment days. Overnight storage of products with leukocyte count > 300 x 10(9)/1 has longer leukocyte (P = 0.03) and platelet (P = 0.01) engraftment days compared to other groups. Overnight storage without adding any medium or plasma for the apheresis product with leukocyte count of less than 300 x 109/1 in a commercially available refrigerator can easily and safely be used in transplantation centers. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：313 / 319

页数：7

共 20 条

[1]

AGER S, 1995, BONE MARROW TRANSPL, V16, P633

[2]

AVELLO J, 1997, TRANSFUSION S, V37, pS81

[3]

Beaujean F, 1996, J Hematother, V5, P681, DOI 10.1089/scd.1.1996.5.681

[4] NONCRYOPRESERVED, LIMITED NUMBER (1 OR 2) PERIPHERAL-BLOOD PROGENITOR-CELL (PBPC) COLLECTIONS FOLLOWING GCSF ADMINISTRATION PROVIDE ADEQUATE HEMATOLOGIC SUPPORT FOR HIGH-DOSE CHEMOTHERAPY [J].

BEZWODA, WR ;

DANSEY, R ;

SEYMOUR, L ;

GLENCROSS, D .

HEMATOLOGICAL ONCOLOGY, 1994, 12 (03) :101-110

[5]

DONMEZ A, 2003, EGE J MED, V42, P1

[6]

HALEY R, 1997, TRANSFUSION S, V37, P97

[7] Storage of noncryopreserved periphered blood stem cells for transplantation [J].

Hechler, G ;

Weide, R ;

Heymanns, J ;

Koppler, H ;

Havemann, K .

ANNALS OF HEMATOLOGY, 1996, 72 (05) :303-306

[8] 1997 guidelines for the use of antimicrobial agents in neutropenic patients with unexplained fever [J].

Hughes, WT ;

Armstrong, D ;

Bodey, GP ;

Brown, AE ;

Edwards, JE ;

Feld, R ;

Pizzo, P ;

Rolston, KVI ;

Shenep, JL ;

Young, LS .

CLINICAL INFECTIOUS DISEASES, 1997, 25 (03) :551-573

[9] 2002 guidelines for the use of antimicrobial agents in neutropenic patients with cancer [J].

Hughes, WT ;

Armstrong, D ;

Bodey, GP ;

Bow, EJ ;

Brown, AE ;

Calandra, T ;

Feld, R ;

Pizzo, PA ;

Rolston, KVI ;

Shenep, JL ;

Young, LS .

CLINICAL INFECTIOUS DISEASES, 2002, 34 (06) :730-751

[10] Peripheral blood progenitor cell transplantation [J].

Jansen, J ;

Thompson, JM ;

Dugan, MJ ;

Nolan, P ;

Wiemann, MC ;

Birhiray, R ;

Henslee-Downey, PJ ;

Akard, LP .

THERAPEUTIC APHERESIS, 2002, 6 (01) :5-14

← 1 2 →