Cellular HIV-1 restriction factors: a new avenue for AIDS therapy?

被引：2
作者：
Barr, Stephen D. [1 ]
机构：
[1] Univ Western Ontario, Dept Microbiol & Immunol, London, ON, Canada
来源：
FUTURE VIROLOGY | 2010年 / 5卷 / 04期
基金：
加拿大健康研究院;
关键词：
2; 5 '-oligoadenylate synthetase; apolipoprotein B mRNA editing enzyme catalytic polypeptide-like 3; HIV; innate immunity; interferon; interferon-stimulated gene; protein kinase R; restriction factors; tetherin; tripartite motif; HUMAN-IMMUNODEFICIENCY-VIRUS; DEPENDENT PROTEIN-KINASE; MURINE LEUKEMIA-VIRUS; HEPATITIS-C VIRUS; LOCUS AFFECTING RESISTANCE; APOBEC3G GENETIC-VARIANTS; INNATE ANTIVIRAL RESPONSE; MESSENGER-RNA LEVELS; SINGLE-STRANDED RNA; PKR CDNA CONSTRUCT;
D O I：
10.2217/FVL.10.36
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The lack of an efficacious HIV-1 vaccine and the continued emergence of drug-resistant HIV-1 strains have pushed the research community to explore novel avenues for AIDS therapy. Over the last decade, one new avenue that has been realized involves cellular HIV-1 restriction factors, defined as host cellular proteins or factors that restrict or inhibit HIV-1 replication. Many of these factors are interferon-induced and inhibit specific stages of the HIV-1 lifecycle that are not targeted by current AIDS therapies. Our understanding of the molecular mechanisms underlying HIV-1 restriction is far from complete, but our current knowledge of these factors offers hope for the future development of novel therapeutic ideas.
引用
收藏
页码：417 / 433
页数：17
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