Palladium-catalyzed selective N-(hetero)arylation or N,N′-di(hetero)arylation of 1-aminoindoles

被引：14
作者：
Messaoudi, Samir [1 ]
Brion, Jean-Daniel [1 ]
Alami, Mouad [1 ]
机构：
[1] Univ Paris Sud, CNRS, BioCIS UMR 8076, Lab Chim Therapeut,Fac Pharm, F-92296 Chatenay Malabry, France
来源：
TETRAHEDRON LETTERS | 2011年 / 52卷 / 21期
关键词：
Palladium; Amination; Cross-coupling; N-Substituted; 1-aminoindoles; Homogeneous catalysis; N-ARYLATION; DERIVATIVES; INHIBITORS; NOVOBIOCIN; HYDRAZINES; CHEMISTRY; INDOLES; ANALOGS; PROFILE; ACCESS;
D O I：
10.1016/j.tetlet.2011.03.068
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The selective synthesis of N-(hetero)aryl-1-aminoindoles 3 from the corresponding N-aminoindoles and (hetero)aryl halides using a catalyst combination of Pd-2(dba)(3) associated to Josiphos is described. By switching to Xantphos as the ligand, the alternate catalytic system allows the coupling to proceed efficiently for the preparation of symmetrical and unsymmetrical N,N'-diaryl-1-aminoindole derivatives in good yields. (C) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2687 / 2691
页数：5
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