Polycyclic aromatic alkaloids .11. A convenient formal total synthesis of the cytotoxic marine alkaloid amphimedine

被引：0

作者：

Bracher, F

Papke, T

机构：

来源：

LIEBIGS ANNALEN | 1996年 / 01期

关键词：

amphimedine; alkaloid; palladium catalyst; cross coupling; anellation;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The pyridylbenzo[c][2,7]naphthyridinone 2, a central intermediate for the total synthesis of amphimedine (1), was prepared in two steps from the readily available quinoline 3. Palladium-catalyzed cross-coupling of 3 with 4-(trimethylstannyl)pyridine gave the biarene 4, which could be converted to the target compound 2 by using a one-pot anellation method.

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页码：115 / 116

页数：2

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