Tumor Targeting, Trifunctional Dendritic Wedge

被引：14

作者：

Dubey, Ramin ^{[1
]}

Kushal, Swati ^{[1
]}

Mollard, Alexis ^{[2
]}

Vojtovich, Lesya ^{[1
]}

Oh, Philip ^{[3
]}

Levin, Michael D. ^{[3
]}

Schnitzer, Jan E. ^{[3
]}

Zharov, Ilya ^{[2
]}

Olenyuk, Bogdan Z. ^{[1
]}

机构：

[1] Univ So Calif, Dept Pharmacol & Pharmaceut Sci, Los Angeles, CA 90089 USA

[2] Univ Utah, Dept Chem, Salt Lake City, UT 84112 USA

[3] Proteogen Res Inst Syst Med, San Diego, CA 92121 USA

来源：

BIOCONJUGATE CHEMISTRY | 2015年 / 26卷 / 01期

基金：

美国国家卫生研究院;

关键词：

NEUTRON-CAPTURE THERAPY; DRUG-DELIVERY; CYANINE DYES; FLUORESCENT-PROBES; NUCLEIC-ACIDS; CANCER; DENDRIMERS; CHEMISTRY; DESIGN; NANOPARTICLES;

D O I：

10.1021/bc500436b

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

We report in vitro and in vivo evaluation of a newly designed trifunctional theranostic agent for targeting solid tumors. This agent combines a dendritic wedge with high boron content for boron neutron capture therapy or boron MRI, a monomethine cyanine dye for visible-light fluorescent imaging, and an integrin ligand for efficient tumor targeting. We report photophysical properties of the new agent, its cellular uptake and in vitro targeting properties. Using live animal imaging and intravital microscopy (IVM) techniques, we observed a rapid accumulation of the agent and its retention for a prolonged period of time (up to 7 days) in fully established animal models of human melanoma and murine mammary adenocarcinoma. This macromolecular theranostic agent can be used for targeted delivery of high boron load into solid tumors for future applications in boron neutron capture therapy.

引用

页码：78 / 89

页数：12

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