Synthesis and characterization of Eu(III)-based coordination complexes of modified D-glucosamine and poly(N-isopropylacrylamide)

被引：10

作者：

Cui, Guihua ^{[1
,2
]}

Zhao, Dehai ^{[2
]}

Lv, Peng ^{[1
]}

Gao, Zhengguo ^{[3
]}

Chen, Shuiying ^{[2
]}

Qiu, Nannan ^{[2
]}

Satoh, Toshifumi ^{[4
]}

Kakuchi, Toyoji ^{[2
,4
]}

Duan, Qian ^{[2
]}

机构：

[1] Jilin Med Univ, Sch Pharm, Changchun 132013, Jilin, Peoples R China

[2] Changchun Univ Sci & Technol, Dept Mat Sci & Engn, Changchun 130022, Jilin, Peoples R China

[3] Yantai Univ, Chem & Engn Coll, Yantai 264005, Shandong, Peoples R China

[4] Hokkaido Univ, Grad Sch Engn, Div Biotechnol & Macromol Chem, Sapporo, Hokkaido 0608628, Japan

来源：

OPTICAL MATERIALS | 2017年 / 72卷

关键词：

D-glucosamine (GA); Poly(N-isopropylacrylamide) (PNIPAM); Atom transfer radical polymerization (ATRP); Lower critical solution temperature (LCST); Fluorescence; TUMOR-CELLS; IN-VITRO; LUMINESCENCE; TEMPERATURE; DRUG; VIVO;

D O I：

10.1016/j.optmat.2017.05.051

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

A series of novel fluorescent complexes was formed by chelation of the thermosensitive polymers with europium(III) ions. The polymers was synthesized via atom transfer radical polymerization (ATRP), which composed of poly(N-isopropyl acrylamide) (PNIPAM) and 2-amino-2-deoxy-D-glucopyranose(D-glucosamine, GA). The aqueous solutions of the polymers and its Eu(III) complexes exhibited a lower critical solution temperatures (LCSTs), and which were approximately equal to body temperature. The maximum emission intensity of the complexes at 613 nm was enhanced by a factor of approximately 10 relative to that of the corresponding Eu(III) chloride. Cell viability assays suggested that these thermosensitive polymers and Eu(III) complexes showed excellent biocompatibility in vitro. (C) 2017 Elsevier B.V. All rights reserved.

引用

页码：115 / 121

页数：7

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