Successful retreatment with lenalidomide for relapsed and refractory multiple myeloma previously treated with bortezomib, lenalidomide and pomalidomide

被引：1

作者：

Oka, Satoko ^{[1
]}

Ono, Kazuo ^{[2
]}

Nohgawa, Masaharu ^{[1
]}

机构：

[1] Japanese Red Cross Soc Wakayama Med Ctr, Div Hematol, 4-20 Komatsubaradori, Wakayama, Japan

[2] Japanese Red Cross Soc Wakayama Med Ctr, Div Pathol, Wakayama, Japan

来源：

JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS | 2018年 / 43卷 / 06期

关键词：

bortezomib; extramedullary plasmacytoma; lenalidomide; pomalidomide; relapse and refractory MM (RRMM); DEXAMETHASONE; STRATEGIES; EVENTS; TRIAL;

D O I：

10.1111/jcpt.12740

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

What is known and objectives Optimal strategies for treating patients with very advanced relapsed and refractory multiple myeloma (RRMM) have not been clarified. Case summaryWhat is new and conclusionA 80-year-old patient with RRMM experienced extramedullary relapse following treatment with bortezomib, lenalidomide and pomalidomide. However, he achieved very good partial remission after retreatment with lenalidomide. This report illustrates that patients with very advanced RRMM can still respond to prior therapy even after being exposed and refractory to several agents. Considering the depth or duration of response to prior treatment, retreatment may improve the outcome of frail RRMM.

引用

页码：914 / 917

页数：4

共 13 条

[1] Randomized multicenter phase 2 study of pomalidomide, cyclophosphamide, and dexamethasone in relapsed refractory myeloma [J].

Baz, Rachid C. ;

Martin, Thomas G., III ;

Lin, Hui-Yi ;

Zhao, Xiuhua ;

Shain, Kenneth H. ;

Cho, Hearn J. ;

Wolf, Jeffrey L. ;

Mahindra, Anuj ;

Chari, Ajai ;

Sullivan, Daniel M. ;

Nardelli, Lisa A. ;

Lau, Kenneth ;

Alsina, Melissa ;

Jagannath, Sundar .

BLOOD, 2016, 127 (21) :2561-2568

[2] IMMUNOGLOBULIN-D MULTIPLE-MYELOMA - PRESENTING FEATURES, RESPONSE TO THERAPY, AND SURVIVAL IN A SERIES OF 53 CASES [J].

BLADE, J ;

LUST, JA ;

KYLE, RA .

JOURNAL OF CLINICAL ONCOLOGY, 1994, 12 (11) :2398-2404

[3] Presenting features and prognosis in 72 patients with multiple myeloma who were younger than 40 years [J].

Blade, J ;

Kyle, RA ;

Greipp, PR .

BRITISH JOURNAL OF HAEMATOLOGY, 1996, 93 (02) :345-351

[4]

Blade J, 2009, BLOOD, V114, pSCI

[5] Whole-genome sequencing of multiple myeloma from diagnosis to plasma cell leukemia reveals genomic initiating events, evolution, and clonal tides [J].

Egan, Jan B. ;

Shi, Chang-Xin ;

Tembe, Waibhav ;

Christoforides, Alexis ;

Kurdoglu, Ahmet ;

Sinari, Shripad ;

Middha, Sumit ;

Asmann, Yan ;

Schmidt, Jessica ;

Braggio, Esteban ;

Keats, Jonathan J. ;

Fonseca, Rafael ;

Bergsagel, P. Leif ;

Craig, David W. ;

Carpten, John D. ;

Stewart, A. Keith .

BLOOD, 2012, 120 (05) :1060-1066

[6] Bortezomib Plus Dexamethasone Is Superior to Vincristine Plus Doxorubicin Plus Dexamethasone As Induction Treatment Prior to Autologous Stem-Cell Transplantation in Newly Diagnosed Multiple Myeloma: Results of the IFM 2005-01 Phase III Trial [J].

Harousseau, Jean-Luc ;

Attal, Michel ;

Avet-Loiseau, Herve ;

Marit, Gerald ;

Caillot, Denis ;

Mohty, Mohamad ;

Lenain, Pascal ;

Hulin, Cyrille ;

Facon, Thierry ;

Casassus, Philippe ;

Michallet, Mauricette ;

Maisonneuve, Herve ;

Benboubker, Lotfi ;

Maloisel, Frederic ;

Petillon, Marie-Odile ;

Webb, Iain ;

Mathiot, Claire ;

Moreau, Philippe .

JOURNAL OF CLINICAL ONCOLOGY, 2010, 28 (30) :4621-4629

[7] International Myeloma Working Group consensus criteria for response and minimal residual disease assessment in multiple myeloma [J].

Kumar, Shaji ;

Paiva, Bruno ;

Anderson, Kenneth C. ;

Durie, Brian ;

Landgren, Ola ;

Moreau, Philippe ;

Munshi, Nikhil ;

Lonial, Sagar ;

Blade, Joan ;

Mateos, Maria-Victoria ;

Dimopoulos, Meletios ;

Kastritis, Efstathios ;

Boccadoro, Mario ;

Orlowski, Robert ;

Goldschmidt, Hartmut ;

Spencer, Andrew ;

Hou, Jian ;

Chng, Wee Joo ;

Usmani, Saad Z. ;

Zamagni, Elena ;

Shimizu, Kazuyuki ;

Jagannath, Sundar ;

Johnsen, Hans E. ;

Terpos, Evangelos ;

Reiman, Anthony ;

Kyle, Robert A. ;

Sonneveld, Pieter ;

Richardson, Paul G. ;

McCarthy, Philip ;

Ludwig, Heinz ;

Chen, Wenming ;

Cavo, Michele ;

Harousseau, Jean-Luc ;

Lentzsch, Suzanne ;

Hillengass, Jens ;

Palumbo, Antonio ;

Orfao, Alberto ;

Rajkumar, S. Vincent ;

Miguel, Jesus San ;

Avet-Loiseau, Herve .

LANCET ONCOLOGY, 2016, 17 (08) :E328-E346

[8] Treatment strategies in relapsed and refractory multiple myeloma: a focus on drug sequencing and 'retreatment' approaches in the era of novel agents [J].

Mohty, B. ;

El-Cheikh, J. ;

Yakoub-Agha, I. ;

Avet-Loiseau, H. ;

Moreau, P. ;

Mohty, M. .

LEUKEMIA, 2012, 26 (01) :73-85

[9] Current and New Therapeutic Strategies for Relapsed and Refractory Multiple Myeloma: An Update [J].

Nijhof, Inger S. ;

van de Donk, Niels W. C. J. ;

Zweegman, Sonja ;

Lokhorst, Henk M. .

DRUGS, 2018, 78 (01) :19-37

[10] MEDICAL PROGRESS Multiple Myeloma [J].

Palumbo, Antonio ;

Anderson, Kenneth .

NEW ENGLAND JOURNAL OF MEDICINE, 2011, 364 (11) :1046-1060

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