Accelerated stem cell attachment to ultrafine grained titanium

被引：108

作者：

Estrin, Yuri ^{[1
,2
]}

Ivanova, Elena P. ^{[3
]}

Michalska, Anna ^{[4
]}

Truong, Vi Khanh ^{[3
]}

Lapovok, Rimma ^{[1
]}

Boyd, Richard ^{[4
]}

机构：

[1] Monash Univ, Dept Mat Engn, ARC Ctr Excellence Design Light Met, Clayton, Vic 3800, Australia

[2] CSIRO Div Proc Sci & Engn, Clayton, Vic 3168, Australia

[3] Swinburne Univ Technol, Fac Life & Social Sci, Hawthorn, Vic 3122, Australia

[4] Monash Univ, Monash Immunol & Stem Cell Labs, Clayton, Vic 3800, Australia

来源：

ACTA BIOMATERIALIA | 2011年 / 7卷 / 02期

基金：

澳大利亚研究理事会;

关键词：

Mesenchymal stem cell; Titanium; Cell adhesion; Cell spreading; Nanotopography; SEVERE PLASTIC-DEFORMATION; BIOMEDICAL APPLICATIONS; SURFACE; ROUGHNESS; ADHESION; METALS; ALLOYS; TI;

D O I：

10.1016/j.actbio.2010.09.033

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Commercial purity titanium with an average grain size in the low sub-micron range was produced by equal channel angular pressing (ECAP). Attachment of human bone marrow-derived mesenchymal stem cells (hMSCs) to the surface of conventional coarse grained and ECAP-modified titanium was studied. It was demonstrated that the attachment and spreading of hMSCs in the initial stages (up to 24 h) of culture was enhanced by grain refinement. Surface characterization by a range of techniques showed that the main factor responsible for the observed acceleration of hMSC attachment and spreading on titanium due to grain refinement in the bulk is the attendant changes in surface topography on the nanoscale. These results indicate that, in addition to its superior mechanical properties, ECAP-modified titanium possesses improved biocompatibility, which makes it to a potent candidate for applications in medical implants. (C) 2010 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

引用

页码：900 / 906

页数：7

共 26 条

[1] An in vitro model for mineralization of human osteoblast-like cells on implant materials [J].

Ahmad, M ;

McCarthy, M ;

Gronowicz, G .

BIOMATERIALS, 1999, 20 (03) :211-220

[2] SURFACE CHARACTERIZATION OF PLASMA-NITRIDED TITANIUM - AN XPS STUDY [J].

BERTOTI, I ;

MOHAI, M ;

SULLIVAN, JL ;

SAIED, SO .

APPLIED SURFACE SCIENCE, 1995, 84 (04) :357-371

[3] Surface structure and composition of flat titanium thin films as a function of film thickness and evaporation rate [J].

Cai, KY ;

Müller, M ;

Bossert, J ;

Rechtenbach, A ;

Jandt, KD .

APPLIED SURFACE SCIENCE, 2005, 250 (1-4) :252-267

[4] Accelerated growth of preosteoblastic cells on ultrafine grained titanium [J].

Estrin, Y. ;

Kasper, C. ;

Diederichs, S. ;

Lapovok, R. .

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 2009, 90A (04) :1239-1242

[5] Stem cell-coated titanium implants for the partial joint resurfacing of the knee [J].

Frosch, KH ;

Drengk, A ;

Krause, P ;

Viereckc, V ;

Miosge, N ;

Werner, C ;

Schild, D ;

Stürmer, EK ;

Stürmer, KM .

BIOMATERIALS, 2006, 27 (12) :2542-2549

[6] Roughness parameters [J].

Gadelmawla, ES ;

Koura, MM ;

Maksoud, TMA ;

Elewa, IM ;

Soliman, HH .

JOURNAL OF MATERIALS PROCESSING TECHNOLOGY, 2002, 123 (01) :133-145

[7] Effects of soluble metals on human peri-implant cells [J].

Hallab, NJ ;

Anderson, S ;

Caicedo, M ;

Brasher, A ;

Mikecz, K ;

Jacobs, JJ .

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 2005, 74A (01) :124-140

[8] Quantification of biofilm structures by the novel computer program COMSTAT [J].

Heydorn, A ;

Nielsen, AT ;

Hentzer, M ;

Sternberg, C ;

Givskov, M ;

Ersboll, BK ;

Molin, S .

MICROBIOLOGY-SGM, 2000, 146 :2395-2407

[9] Impact of Nanoscale Roughness of Titanium Thin Film Surfaces on Bacterial Retention [J].

Ivanova, Elena P. ;

Truong, Vi Khanh ;

Wang, James Y. ;

Berndt, Christopher C. ;

Jones, Robert T. ;

Yusuf, Iman I. ;

Peake, Ian ;

Schmidt, Heinrich W. ;

Fluke, Christopher ;

Barnes, David ;

Crawford, Russell J. .

LANGMUIR, 2010, 26 (03) :1973-1982

[10] In vitro fibroblast response to ultra fine grained titanium produced by a severe plastic deformation process [J].

Kim, Taik Nam ;

Balakrishnan, A. ;

Lee, B. C. ;

Kim, W. S. ;

Dvorankova, B. ;

Smetana, K. ;

Park, J. K. ;

Panigrahi, B. B. .

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 2008, 19 (02) :553-557

← 1 2 3 →