Serum lipoprotein(a) is not modified by interleukin-6 receptor antagonism or associated with inflammation in non-ST-elevation myocardial infarction

被引：10
作者：
Ueland, Thor [1 ,2 ,12 ]
Kleveland, Ola [9 ,10 ]
Michelsen, Annika E. [1 ,2 ]
Wiseth, Rune [9 ,10 ]
Damas, Jan Kristian [11 ]
Holven, Kirsten B. [7 ,8 ]
Aukrust, Pal [1 ,2 ,3 ,12 ]
Gullestad, Lars [2 ,4 ,5 ,6 ]
Yndestad, Arne [1 ,2 ,5 ,6 ]
Halvorsen, Bente [1 ,2 ]
机构：
[1] Natl Hosp Norway, Internal Med Res Inst, Oslo Univ Hosp, Oslo, Norway
[2] Natl Hosp Norway, Inst Clin Med, Oslo Univ Hosp, Oslo, Norway
[3] Natl Hosp Norway, Sect Clin Immunol & Infect Dis, Oslo Univ Hosp, Oslo, Norway
[4] Natl Hosp Norway, Dept Cardiol, Oslo Univ Hosp, Oslo, Norway
[5] Univ Oslo, KG Jebsen Ctr Cardiac Res, Oslo, Norway
[6] Oslo Univ Hosp, Ctr Heart Failure Res, Oslo, Norway
[7] Dept Endocrinol Morbid Obes & Prevent Med, Norwegian Natl Advisory Unit Familial Hypercholes, Oslo, Norway
[8] Univ Oslo, Inst Basic Med Sci, Dept Nutr, Fac Med, Oslo, Norway
[9] St Olavs Hosp, Clin Cardiol, Trondheim, Norway
[10] Norwegian Univ Sci & Technol NTNU, Dept Circulat & Med Imaging, Trondheim, Norway
[11] Norwegian Univ Sci & Technol NTNU, Ctr Mol Inflammat Res, Dept Canc Res & Mol, Trondheim, Norway
[12] Univ Tromso, KG Jebsen TREC, Tromso, Norway
来源：
INTERNATIONAL JOURNAL OF CARDIOLOGY | 2019年 / 274卷
关键词：
Lipoprotein(a); Acute coronary syndrome; IL-6; antagonism; Inflammation; RHEUMATOID-ARTHRITIS; RISK; PROTEINS; DISEASE;
D O I：
10.1016/j.ijcard.2018.06.093
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Background: The IL-6 receptor antagonist tocilizumab has been shown to attenuate the proatherogenic lipoprotein a [Lp(a)] in rheumatoid arthritis. We evaluated if a single dose of tocilizumab reduced Lp(a) in patients with non-ST-elevation myocardial infarction (NSTEMI). Methods: Lp(a) was assessed by immunoassay (n = 117 patients) at 7 consecutive time-points between day 1 and 3 and at 3 and 6 months follow-up. Results: Tocilizumab did not affect Lp(a) at any time-point during the study and was not associated with cardiovascular risk factors. Conclusions: Short-time inhibition of IL-6 with tocilizumab in patients with NSTEMI did not influence Lp(a) levels. (c) 2018 Published by Elsevier B.V.
引用
收藏
页码：348 / 350
页数：3
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