Synthesis of Azepinoindoles via Pd-Catalyzed C(sp2)-H Imidoylative Cyclization Reactions

被引：7

作者：

Wang, Jiang ^{[1
]}

Ren, Pinzhuo ^{[1
]}

Gu, Gongping ^{[1
]}

Jiang, Zongyou ^{[1
]}

Xiang, Bolin ^{[1
]}

Tang, Shi ^{[1
,2
]}

Jia, Ai-Qun ^{[1
]}

机构：

[1] Hainan Univ, Hlth Inst 1, Sch Pharmaceut Sci, Key Lab Trop Biol Resources,Minist Educ, Haikou 570228, Hainan, Peoples R China

[2] Anhui Normal Univ, Coll Chem & Mat Sci, Anhui Lab Mol Based Mat, Wuhu 241002, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2022年 / 87卷 / 15期

基金：

中国国家自然科学基金;

关键词：

CYCLOADDITION REACTION; PICTET-SPENGLER; CASCADE; CONSTRUCTION; INHIBITORS; ALKALOIDS; ARYLATION; INDOLES; ACCESS; INDOLOBENZAZEPINONES;

D O I：

10.1021/acs.joc.2c00717

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient and convenient method for the construction of diverse free (N-H)-benzazepinoindoles by Pd-catalyzed C(sp(2))-H imidoylative cyclization of 3-(2-isocyanobenzyl)-1H-indoles was developed. The reaction shows a wide substrate scope and can be scaled up, providing a practical route to valuable bioactive azepinoindoles.

引用

页码：9663 / 9674

页数：12

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