Intracytoplasmic Re-localization of miRISC Complexes

被引：17

作者：

Akgul, Bunyamin ^{[1
]}

Erdogan, Ipek ^{[1
]}

机构：

[1] Izmir Inst Technol, Dept Mol Biol & Genet, Noncoding RNA Lab, Urla, Turkey

来源：

FRONTIERS IN GENETICS | 2018年 / 9卷

关键词：

microRNA; localization; polysome; mRNP; translational repression; MICRORNA-DEPENDENT LOCALIZATION; MESSENGER-RNA TARGETS; HUMAN-CELLS; STRESS GRANULES; PROCESSING BODIES; ENDOPLASMIC-RETICULUM; MAMMALIAN MICRORNAS; P-BODIES; POSTTRANSCRIPTIONAL REGULATION; TRANSLATIONAL REPRESSION;

D O I：

10.3389/fgene.2018.00403

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

MicroRNAs (miRNAs) are a conserved class of non-coding RNAs of 22 nucleotides that post-transcriptionally regulate gene expression through translational repression and/or mRNA degradation. A great progress has been made regarding miRNA biogenesis and miRNA-mediated gene regulation. Additionally, an ample amount of information exists with respect to the regulation of miRNAs. However, the cytoplasmic localization of miRNAs and its effect on gene regulatory output is still in progress. We provide a current review of the cytoplasmic miRNA localization in metazoans. We then discuss the dynamic changes in the intracytoplasmic localization of miRNAs as a means to regulate their silencing activity. We then conclude our discussion with the potential molecules that could modulate miRNA localization.

引用

页数：7

共 81 条

[1] Quantifying mRNA targeting to P-bodies in living human cells reveals their dual role in mRNA decay and storage [J].

Aizer, Adva ;

Kalo, Alon ;

Kafri, Pinhas ;

Shraga, Amit ;

Ben-Yishay, Rakefet ;

Jacob, Avi ;

Kinor, Noa ;

Shav-Tal, Yaron .

JOURNAL OF CELL SCIENCE, 2014, 127 (20) :4443-4456

[2] Stress granules: The Tao of RNA triage [J].

Anderson, Paul ;

Kedersha, Nancy .

TRENDS IN BIOCHEMICAL SCIENCES, 2008, 33 (03) :141-150

[3] Pre-microRNA and Mature microRNA in Human Mitochondria [J].

Barrey, Eric ;

Saint-Auret, Gaelle ;

Bonnamy, Blandine ;

Damas, Dominique ;

Boyer, Orane ;

Gidrol, Xavier .

PLOS ONE, 2011, 6 (05)

[4] Metazoan MicroRNAs [J].

Bartel, David P. .

CELL, 2018, 173 (01) :20-51

[5] Micromanagers of gene expression: the potentially widespread influence of metazoan microRNAs [J].

Bartel, DP ;

Chen, CZ .

NATURE REVIEWS GENETICS, 2004, 5 (05) :396-400

[6] Ribosome Profiling Shows That miR-430 Reduces Translation Before Causing mRNA Decay in Zebrafish [J].

Bazzini, Ariel A. ;

Lee, Miler T. ;

Giraldez, Antonio J. .

SCIENCE, 2012, 336 (6078) :233-237

[7] Kinetic analysis reveals successive steps leading to miRNA-mediated silencing in mammalian cells [J].

Bethune, Julien ;

Artus-Revel, Caroline G. ;

Filipowicz, Witold .

EMBO REPORTS, 2012, 13 (08) :716-723

[8] Relief of microRNA-mediated translational repression in human cells subjected to stress [J].

Bhattacharyya, Suvendra N. ;

Habermacher, Regula ;

Martine, Ursula ;

Closs, Ellen I. ;

Filipowicz, Witold .

CELL, 2006, 125 (06) :1111-1124

[9] Target-dependent biogenesis of cognate microRNAs in human cells [J].

Bose, Mainak ;

Bhattacharyya, Suvendra N. .

NATURE COMMUNICATIONS, 2016, 7

[10] RETRACTED: mRNP granules Assembly, function, and connections with disease (Retracted Article) [J].

Buchan, J. Ross .

RNA BIOLOGY, 2014, 11 (08) :1019-1030

← 1 2 3 4 5 6 7 8 9 →