Drug-Induced Interstitial Lung Disease: A Systematic Review

被引：280

作者：

Skeoch, Sarah ^{[1
,2
]}

Weatherley, Nicholas ^{[3
]}

Swift, Andrew J. ^{[3
]}

Oldroyd, Alexander ^{[1
]}

Johns, Christopher ^{[3
]}

Hayton, Conal ^{[4
]}

Giollo, Alessandro ^{[5
,6
]}

Wild, James M. ^{[3
]}

Waterton, John C. ^{[7
,8
]}

Buch, Maya ^{[5
]}

Linton, Kim ^{[9
]}

Bruce, Ian N. ^{[1
,10
]}

Leonard, Colm ^{[4
]}

Bianchi, Stephen ^{[11
]}

Chaudhuri, Nazia ^{[4
]}

机构：

[1] Univ Manchester, Div Musculoskeletal & Dermatol Sci, Arthrit Res UK Ctr Epidemiol,Sch Biol Sci, Fac Biol Med & Hlth,Manchester Acad Hlth Sci Ctr, Manchester M13 9PL, Lancs, England

[2] Royal United Hosp Bath NHS Fdn Trust, Royal Natl Hosp Rheumat Dis, Bath BA1 1RL, Avon, England

[3] Univ Sheffield, Dept Infect Immun & Cardiovasc Dis, Sheffield S10 2TN, S Yorkshire, England

[4] Manchester Univ NHS Fdn Trust, Manchester Acad Hlth Sci Ctr, North West Lung Ctr, Salford M6 8HD, Lancs, England

[5] Univ Leeds, NIHR Leeds Biomed Res Ctr, Leeds Inst Rheumat & Musculoskeletal Med, Leeds LS2 9JT, W Yorkshire, England

[6] Univ Verona, Dept Med, Rheumatol Unit, I-37134 Verona, Italy

[7] Bioxydyn Ltd, Rutherford House,Manchester Sci Pk, Manchester M15 6SZ, Lancs, England

[8] Univ Manchester, Manchester Acad Hlth Sci Ctr, Div Informat Imaging & Data Sci, Ctr Imaging Sci,Sch Hlth Sci,Fac Biol Med & Hlth, Manchester M13 9PL, Lancs, England

[9] Univ Manchester, Manchester Acad Hlth Sci Ctr, Fac Biol Med & Hlth, Div Canc Sci,Sch Med Sci, Manchester M13 9PL, Lancs, England

[10] Manchester Univ NHS Fdn Trust, Manchester Acad Hlth Sci Ctr, NIHR Manchester Biomed Res Ctr, Kellgren Ctr Rheumatol, Salford M6 8HD, Lancs, England

[11] Sheffield Teaching Hosp NHS Fdn Trust, Acad Directorate Resp Med, Sheffield S10 2JF, S Yorkshire, England

来源：

JOURNAL OF CLINICAL MEDICINE | 2018年 / 7卷 / 10期

基金：

欧盟地平线“2020”;

关键词：

drug-induced interstitial lung disease; pulmonary toxicity; drug-induced pneumonitis; RESOLUTION COMPUTED-TOMOGRAPHY; OF-THE-LITERATURE; INHIBITOR-RELATED PNEUMONITIS; GEMCITABINE PLUS ERLOTINIB; THIN-SECTION CT; PULMONARY TOXICITY; RISK-FACTORS; BRONCHOALVEOLAR LAVAGE; RHEUMATOID-ARTHRITIS; JAPANESE PATIENTS;

D O I：

10.3390/jcm7100356

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Drug-induced interstitial lung disease (DIILD) occurs as a result of numerous agents, but the risk often only becomes apparent after the marketing authorisation of such agents. Methods: In this PRISMA-compliant systematic review, we aimed to evaluate and synthesise the current literature on DIILD. Results: Following a quality assessment, 156 full-text papers describing more than 6000 DIILD cases were included in the review. However, the majority of the papers were of low or very low quality in relation to the review question (78%). Thus, it was not possible to perform a meta-analysis, and descriptive review was undertaken instead. DIILD incidence rates varied between 4.1 and 12.4 cases/million/year. DIILD accounted for 3-5% of prevalent ILD cases. Cancer drugs, followed by rheumatology drugs, amiodarone and antibiotics, were the most common causes of DIILD. The radiopathological phenotype of DIILD varied between and within agents, and no typical radiological pattern specific to DIILD was identified. Mortality rates of over 50% were reported in some studies. Severity at presentation was the most reliable predictor of mortality. Glucocorticoids (GCs) were commonly used to treat DIILD, but no prospective studies examined their effect on outcome. Conclusions: Overall high-quality evidence in DIILD is lacking, and the current review will inform larger prospective studies to investigate the diagnosis and management of DIILD.

引用

页数：30

共 140 条

[1] Drug-induced pneumonitis: Thin-section CT findings in 60 patients [J].