Spleen tyrosine kinase as a molecular target for treatment of leukemias and lymphomas

被引：20

作者：

Uckun, Fatih M. ^{[1
,2
]}

Qazi, Sanjive ^{[3
]}

机构：

[1] Childrens Hosp Los Angeles, Dev Therapeut Program, Inst Pediat Clin Res, Los Angeles, CA 90027 USA

[2] Univ So Calif, Dept Pediat, Div Hematol Oncol, Sch Med,Childrens Ctr Canc & Blood Dis, Los Angeles, CA 90027 USA

[3] Gustavus Adolphus Coll, St Peter, MN 56082 USA

来源：

EXPERT REVIEW OF ANTICANCER THERAPY | 2010年 / 10卷 / 09期

关键词：

leukemia; lymphoma; nanotechnology; rational drug design; RNA interference; spleen tyrosine kinase; tyrosine kinase inhibitor; ACUTE LYMPHOBLASTIC-LEUKEMIA; CELL ANTIGEN RECEPTOR; CHILDRENS-ONCOLOGY-GROUP; PRIMARY CLONOGENIC BLASTS; NON-HODGKIN-LYMPHOMA; BONE-MARROW RELAPSE; B-CELLS; PHOSPHOINOSITIDE; 3-KINASE; APOPTOTIC RESISTANCE; THERAPEUTIC TARGET;

D O I：

10.1586/ERA.10.112

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Spleen tyrosine kinase (SYK) has emerged as a potential molecular target for the treatment of B-lineage leukemias and lymphomas. Here, we provide an overview of the current state of knowledge regarding the regulatory signaling function of SYK and its role in the pathogenesis of B-lineage lymphoid malignancies, available methods and drug candidates for targeting SYK, as well as compelling preclinical and clinical evidence regarding the clinical potential of inhibiting SYK. The further development of rationally designed SYK inhibitors may provide the foundation for therapeutic innovation against B-lineage leukemias and lymphomas.

引用

页码：1407 / 1418

页数：12

共 50 条

[21] Discovery of TAK-659 an orally available investigational inhibitor of Spleen Tyrosine Kinase (SYK) [J].

Lam, Betty ;

Arikawa, Yasuyoshi ;

Cramlett, Joshua ;

Dong, Qing ;

de Jong, Ron ;

Feher, Victoria ;

Grimshaw, Charles E. ;

Farrell, Pamela J. ;

Hoffman, Isaac D. ;

Jennings, Andy ;

Jones, Benjamin ;

Matuszkiewicz, Jennifer ;

Miura, Joanne ;

Miyake, Hiroshi ;

Natala, Srinivasa Reddy ;

Shi, Lihong ;

Takahashi, Masashi ;

Taylor, Ewan ;

Wyrick, Corey ;

Yano, Jason ;

Zalevsky, Jonathan ;

Nie, Zhe .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2016, 26 (24) :5947-5950

[22] Bruton tyrosine kinase inhibitors: a promising novel targeted treatment for B cell lymphomas [J].

Aalipour, Amin ;

Advani, Ranjana H. .

BRITISH JOURNAL OF HAEMATOLOGY, 2013, 163 (04) :436-443

[23] Leukemias and lymphomas: Treatment and prophylaxis of the central nervous system [J].

Franklin J.L. ;

Finlay J. .

Current Treatment Options in Neurology, 2006, 8 (4) :335-345

[24] Application of recombinant interferons in treatment of malignant lymphomas and leukemias [J].

Butenko, AK .

EXPERIMENTAL ONCOLOGY, 1998, 20 (3-4) :180-190

[25] IL-21 Enhances Phagocytosis in Mononuclear Phagocyte Cells: Identification of Spleen Tyrosine Kinase as a Novel Molecular Target of IL-21 [J].

Vallieres, Francis ;

Girard, Denis .

JOURNAL OF IMMUNOLOGY, 2013, 190 (06) :2904-2912

[26] NCCN Task Force Report: Molecular Markers in Leukemias and Lymphomas [J].

Radich, Jerald P. ;

Zelenetz, Andrew D. ;

Chan, Wing C. ;

Croce, Carlo M. ;

Czuczman, Myron S. ;

Erba, Harry P. ;

Horning, Sandra J. ;

Houldsworth, Jane ;

Smith, B. Douglas ;

Snyder, David S. ;

Sundar, Hema M. ;

Wetzler, Meir ;

Winter, Jane N. .

JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK, 2009, 7 :S1-S34

[27] 3D QSAR AND MOLECULAR DOCKING STUDIES OF FLAVONOIDS AS SPLEEN TYROSINE KINASE INHIBITORS [J].

Basu, A. ;

Sarkar, A. ;

Basak, P. .

INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH, 2018, 9 (05) :1921-1928

[28] Discovery and Development of Spleen Tyrosine Kinase (SYK) Inhibitors [J].

Singh, Rajinder ;

Masuda, Esteban S. ;

Payan, Donald G. .

JOURNAL OF MEDICINAL CHEMISTRY, 2012, 55 (08) :3614-3643

[29] Identification of a novel series of azabenzimidazole-derived inhibitors of spleen tyrosine kinase [J].

Kawatkar, Sameer P. ;

Barlaam, Bernard ;

Kemmitt, Paul ;

Simpson, Iain ;

Watson, David ;

Wang, Peng ;

Lamont, Scott ;

Su, Qibin ;

Boiko, Scott ;

Ikeda, Timothy ;

Patel, Joe ;

Pike, Andy ;

Pollard, Hannah ;

Read, Jon ;

Sarkar, Ujjal ;

Wang, Haiyun ;

Wen, Quanshan ;

Yan, Zhiyuan ;

Dowling, James E. ;

Dry, Hannah ;

Edmondson, Scott D. .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2020, 30 (18)

[30] Discovery of potent and selective Spleen Tyrosine Kinase inhibitors for the topical treatment of inflammatory skin disease [J].

Barker, Michael D. ;

Liddle, John ;

Atkinson, Francis L. ;

Wilson, David Matthew ;

Dickson, Marion C. ;

Ramirez-Molina, Cesar ;

Lewis, Huw ;

Davis, Rob P. ;

Somers, Donald O. ;

Neu, Margarete ;

Jones, Emma ;

Watson, Robert .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018, 28 (21) :3458-3462

← 1 2 3 4 5 →