Understanding Human Epidermal Stem Cells at Single-Cell Resolution

被引：12
|
作者：
Negri, Victor Augusti [1 ]
Watt, Fiona M. [1 ,2 ]
机构：
[1] Kings Coll London, Sch Basic & Med Biosci, Fac Life Sci & Med, Ctr Gene Therapy & Regenerat Med, London, England
[2] European Mol Biol Lab, Directors Res Unit, Heidelberg, Germany
来源：
JOURNAL OF INVESTIGATIVE DERMATOLOGY | 2022年 / 142卷 / 08期
基金：
英国惠康基金; 英国医学研究理事会;
关键词：
LABEL-RETAINING CELLS; CONSTRAINED POSITIVE SELECTION; TRANSIT-AMPLIFYING CELLS; TERMINAL DIFFERENTIATION; CANCER MUTATIONS; SKIN; EXPRESSION; PROLIFERATION; FATE; KERATINOCYTES;
D O I：
10.1016/j.jid.2022.04.003
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
The human epidermis is one of the first tissues in which the existence of stem cells was recognized and is one of the few in which ex vivo expansion for tissue repair is established clinically. Nevertheless, the nature of stem cells has been elusive. Using clonal growth assays of cultured keratinocytes as a quantitative measure of their abundance, several candidate stem cell markers have been described. Recently, the volume and quality of single-cell RNA-sequencing datasets have increased exponentially, providing new opportunities to explore the nature of epidermal stem cells and test the validity of in vitro experimental models.
引用
收藏
页码：2061 / 2067
页数：7
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